Inflammation in the neonatal period and intrauterine growth restriction aggravate bronchopulmonary dysplasia
To investigate the hematological features of infants with bronchopulmonary dysplasia (BPD) and their relationships with clinical severity.
CONCLUSIONS In hyperoxia-induced rat models of BPD, hBD2 promotes alveolarization and improves pulmonary function. The mechanism may contribute in alleviating inflammation response and inhibiting pro-inflammatory factors including IL-1ß, IL-6, and TNF-alpha. PMID: 31411185 [PubMed - in process]
Journal of Perinatology, Published online: 14 August 2019; doi:10.1038/s41372-019-0465-zTranspyloric feeds and bronchopulmonary dysplasia
AbstractBackgroundBronchopulmonary dysplasia (BPD) is the need for oxygen therapy at 36 weeks postmenstrual age (PMA). Sildenafil has been shown to enhance the lung alveolarization and vascularization in newborn animal models after lung injury and has possible therapeutic potential for the prevention of BPD.ObjectiveTo perform a proof-of-concept, Phase II, pilot randomized, double-blind, clinical trial to study the efficacy of sildenafil in preventing BPD, in postnatal (
Abstract Hyperoxia exposure in premature infants increases the risk of subsequent lung diseases such as asthma and bronchopulmonary dysplasia. Fibroblasts help maintain bronchial and alveolar integrity. Thus understanding mechanisms by which hyperoxia influences fibroblasts is critical. Cellular senescence is increasingly recognized as important to pathophysiology of multiple diseases. We hypothesized that clinically-relevant moderate hyperoxia (
CONCLUSION: Thus, our findings suggest that miR199a-5p is a potential target for attenuating HALI pathophysiology in the developing lung. Moreover, miR199a-5p-inhibitor could be part of a novel therapeutic strategy for improving BPD in preterm neonates. PMID: 31390652 [PubMed - as supplied by publisher]
Conclusion: In the experienced centres, percutaneous ASD closure can be done effectively and safely in symptomatic children weighing less than 10 kg. PMID: 31379261 [PubMed - as supplied by publisher]
Journal of Perinatology, Published online: 07 August 2019; doi:10.1038/s41372-019-0444-4Neonatal ibuprofen exposure and bronchopulmonary dysplasia in extremely premature infants
Publication date: Available online 3 August 2019Source: Respiratory Physiology &NeurobiologyAuthor(s): Abhrajit Ganguly, Richard J. MartinAbstractLonger term respiratory morbidity is a frequent concern for former preterm infants. Increased airway reactivity and wheezing disorders are extremely common in this population, both in infants who meet diagnostic criteria for bronchopulmonary dysplasia [BPD], and in the absence of this diagnosis. It is, therefore, imperative to gain a better understanding of normal and abnormal postnatal development of the immature airway. Airway hyperreactivity may be secondary to abnormal br...
Abstract In the neonatal intensive care unit (NICU), heart rate, respiratory rate, and oxygen saturation are vital signs (VS) that are continuously monitored in infants, while blood pressure is often monitored continuously immediately after birth, or during critical illness. Although changes in VS can reflect infant physiology or circadian rhythms, persistent deviations in absolute values or complex changes in variability can indicate acute or chronic pathology. Recent studies demonstrate that analysis of continuous VS trends can predict sepsis, necrotizing enterocolitis, brain injury, bronchopulmonary dysplasia, ...