Sternal reconstruction with bone cement block using the rigid plate fixation technique

Chest computed tomography demonstrated a suspected primary tumor in the upper sternal body of a 48 ‐year‐old woman who presented with sternal pain. After being diagnosed with chondrosarcoma, she underwent sternal resection. Subsequent chest wall reconstruction was performed after careful planning using a bone cement block made of polypropylene mesh and polymethylmethacrylate. The block was fi xed to the manubrium and ribs using the SternaLock System. She was discharged following an uneventful postoperative recovery, and is currently undergoing follow‐up.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: CASE REPORT Source Type: research

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ConclusionsThis study is continuing to enroll pts and will identify the recommended dose of ADCT-601. Updated results, including pharmacokinetic data, will be presented at the meeting.Clinical trial identificationNIH (https://clinicaltrials.gov/ct2/show/NCT03700294) October 9, 2018.Editorial acknowledgementEditorial support was provided by Sindhu Doppalapudi and Becky Salisbury at Fishawack Communications Ltd, funded by ADC Therapeutics Ltd.Legal entity responsible for the studyADC Therapeutics.FundingADC Therapeutics.DisclosureA.W. Tolcher: Advisory / Consultancy, Research grant / Funding (institution): AbbVie; Advisory /...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Bayer data at ESMO 2019 highlights innovation in cancer researchNew data for larotrectinib on durability of response in patients with TRK fusion cancer to be presented in a poster discussion on September 28 / Data from Bayer's prostate cancer franchise to be presented, including clinical relevance of drug-drug interactions in men with nmCRPC taking darolutamide and real-world data and pain evalutation data in men with mCRPC treated with radium-223 dichloride / New analyses from the Phase II study REGOBONE evaluating the efficacy and safety of regorafenib in patients with rare locally advanced or metastatic relapsed chondro...
Source: Bayer IR Newsfeed: Events - Category: Pharmaceuticals Source Type: news
Conclusions: The proposed nomogram is a reliable and robust tool for accurate prognostic prediction in patients with extremity soft tissue LMS. Introduction Soft tissue leiomyosarcoma (LMS) is an aggressive sarcoma, which originates from smooth muscle cells (1). Soft tissue LMS accounts for about 5–10% of all soft tissue sarcomas (2). It occurs in different sites, including the retroperitoneum, intraabdominal sites, and extremities (3). Extremity LMS comprised about 10–15% of extremity sarcomas, with a preference for the lower limb (4–6). Extremity LMS tends to have a better prognosis than uterine...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion: To our knowledge, this case is the first report of a chest wall reconstruction of a large inferior sternal defect using only polypropylene and omentum without a rigid support or muscular flap. This repair option could be considered for patients in whom traditional rigid repair methods have potential complications or limitations. PMID: 30258302 [PubMed]
Source: Ochsner Journal - Category: General Medicine Tags: Ochsner J Source Type: research
We report a new case of this disease. A 35-year-old man, presented with flank pain, episodic gross hematuria and a painless palpable mass in left abdominal quadrant. Computed tomography scan identified a left renal tumor with 20 cm, with no evidence of regional or metastatic spread disease. The patient underwent radical nephrectomy. The immunohistopathological diagnosis was mesenchymal chondrosarcoma of the kidney. At 18 months of follow-up, there was no evidence of recurrence or distant metastasis. Primary renal chondrosarcoma is so rare that its prognosis is unknown. Disease recurrence is unpredictable and when it is det...
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
Authors: Hardes J, Gosheger G, Budny T Abstract Bone sarcomas are extremely rare representing approximately 0.2% among all cancer types. Due to the rarity of these tumors both the patients and the physicians can overlook or misinterpret the first often unspecific symptoms of these tumors (pain, limping and swelling). Therefore, radiographic examination (X-ray and/or MRI) of the involved region in case of inexplicable symptoms is strongly recommended. The most common primary malignant bone tumor entity is osteosarcoma, followed by chondrosarcoma and Ewing sarcoma. Osteosarcomas and Ewing sarcomas occur predominantly...
Source: Zeitschrift fur Orthopadie und Unfallchirurgie - Category: Orthopaedics Tags: Z Orthop Unfall Source Type: research
Anatomics said this month that a custom 3D-printed implant it created was successfully implanted to replace the sternum and partial ribcage of a 20-year old patient who had lost significant bone mass to Chondrosarcoma, touting the procedure as a 1st for the US. The implant was composed of composite titanium and porous polyethylene designed using high-resolution CT scans of the patient’s chest, approved by an operating surgeon. The implant was only the 2nd of its kind to use the company’s PoreStar technology, though Anatomics has been innovating in the field of 3D printing for over 2 decades. Anatomics has been ...
Source: Mass Device - Category: Medical Devices Authors: Tags: Implants Research & Development Surgical anatomics Source Type: news
Dr. Vincent Ng is an orthopaedic oncologist with the University of Maryland Greenebaum Comprehensive Cancer Center and an Assistant Professor or Orthopaedics with the University of Maryland School of Medicine.  Dr. Ng specializes in treating bone cancer and soft tissue sarcoma.  Below he answers common questions about orthopaedic oncology. What is an orthopaedic oncologist? How do they differ from surgical oncologists? “An orthopaedic oncologist specializes in bone and soft tissue tumors.  I treat any adult or pediatric patient with any bone or soft tissue tumor/lesion/mass, whether benign or malignan...
Source: Life in a Medical Center - Category: Universities & Medical Training Authors: Tags: Cancer Doctors bone cancer oncology orthopedics Source Type: blogs
Actress Charlotte Rae, 91, has revealed that she was just diagnosed with bone cancer. And like many who get a diagnosis of a serious illness at an advanced age, her first decision wasn’t what the best treatment plan might be but rather whether she should seek treatment at all. “At the age of 91, I have to make up my mind,” she told People magazine. “I’m not in any pain right now. I’m feeling so terrific and so glad to be above ground.” Rae, who was treated for pancreatic cancer several years ago, added, “Now I have to figure out whether I want to go have treatment again ...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
We report a case of a 44-year-old man with a localized right renal pelvis mass treated with a right nephroureterectomy. The pathological examination showed a high-grade urothelial carcinoma of the renal pelvis, stage III (pT3aNxM0). A few days later, he developed lower back pain, hematuria, cough with hemoptoic sputum and progressive dyspnea. Radiological explorations showed multiple bilateral lung nodules and a retroperitoneal mass. A CT-guided biopsy of the retroperitoneal mass revealed a high-grade angiosarcoma. A review of the nephrectomy specimen showed a microscopic focus of angiosarcoma in the urothelial carcinoma. ...
Source: Cancer Biology and Therapy - Category: Cancer & Oncology Authors: Tags: Cancer Biol Ther Source Type: research
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