The case for dosimetry in I-131 therapy of differentiated thyroid carcinoma.

The case for dosimetry in I-131 therapy of differentiated thyroid carcinoma.
Q J Nucl Med Mol Imaging. 2019 Jul 01;:
Authors: Verburg FA
Abstract
For advanced DTC several I-131 activity selection strategies are available 1-5. The most commonly practised approach concerns the empirical activity selection, in which the physician chooses an activity based on convention, experience and patient related parameters. The second available strategy is to perform lesion dosimetry. In this case, the activity to be administered is determined after a pretherapeutic dosimetric assessment to calculate the minimal activity required to achieve an effective absorbed dose or a maximum safe activity based on the delivered blood /bone marrow absorbed dose of 2 Gy as determined by blood and whole-body measurements. In contrast to the situation for lesion-based dosimetry, for the maximum safe activity-based approach several studies on outcome are available. In the present paper an argument for the use of dosimetry in advanced DTC will be presented.
PMID: 31271272 [PubMed - as supplied by publisher]

Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - July 6, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research