Endothelial and left ventricular diastolic function in young adults exposed to tobacco.

Endothelial and left ventricular diastolic function in young adults exposed to tobacco. Can J Physiol Pharmacol. 2019 Jul 03;: Authors: Rodriguez-Portelles A, Rodriguez Leyva D Abstract Smoking is associated to endothelial and left ventricular diastolic disfunction. We aimed to determine the endothelial and diastolic function in young adults exposed to tobacco smoke and the effects of acute exposure to it. Smokers were considered as cases and non smokers as controls. Brachial artery diameter, brachial artery flow velocity and echocardiographic variables were measured. Average age of the participants was 21 years old. Smokers showed significant endothelial dysfunction compared to non-smokers. Arterial dilatation mediated by the endothelium was significantly higher in non-smokers than in smokers (p=0.005). Non-endothelium mediated arterial dilatation was significantly impaired in smokers compared to non-smokers (p=0.02). After reactive hyperaemia there was a significant increase in blood flow in non-smokers (+ 61%) than in the smokers group (+29%). Acute cigarette exposure showed a trend towards left ventricle diastolic disfunction in smokers. Left atrium diameter was significant higher in smokers than in non smokers. After acute exposure to cigarette smoke, arterial dilatation and brachial flow velocity were lower than those achieved in the abstinence phase (p=0.05). We concluded that endothelium-dependent arterial dilation is impaire...
Source: Canadian Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Can J Physiol Pharmacol Source Type: research