Public Knowledge of, Perceptions About and Attitudes Towards Dementia: A Cross-Sectional Survey Among Lebanese Primary Health Care Attenders.
Public Knowledge of, Perceptions About and Attitudes Towards Dementia: A Cross-Sectional Survey Among Lebanese Primary Health Care Attenders. Community Ment Health J. 2019 Jul 03;: Authors: Hamieh N, Sharara E, Salibi N, Mrad P, Chaaya M Abstract Dementia is a leading cause of dependency and disability among older adults. Minimal knowledge, poor attitudes and negative perceptions are barriers of dementia early screening, diagnosis and treatment. This is the first study that assesses knowledge, attitudes and perceptions of dementia among a Middle Eastern population. Two hundred and fifty-four Lebanese adults not having dementia attending primary healthcare centers in the capital of Lebanon were interviewed using an Arabic version of the 2010 Northern Ireland Life and Times survey. The highest proportion of the participants (61%) had low knowledge score. Low knowledge was associated with older age and lower education. The majority had a negative perception towards people living with dementia and these perceptions were significantly different by gender, education and exposure. Participants perceived people with dementia as helpless and dependent. Public interventions should address stigma and increase knowledge while understanding the socio-cultural beliefs associated with dementia. The study calls for policy developments and conducting a qualitative study. PMID: 31270647 [PubMed - as supplied by publisher]
In this study we describe a heterogeneous network-based data set for Alzheimer's disease (HENA). Additionally, we demonstrate the application of state-of-the-art graph convolutional networks, i.e. deep learning methods for the analysis of such large heterogeneous biological data sets. We expect HENA to allow scientists to explore and analyze their own results in the broader context of Alzheimer's disease research. PMID: 31413325 [PubMed - in process]
DISCUSSION: The German version of the CAMDEX-DS provides an internationally recognized tool for the diagnostics and monitoring of cognitive decline in Down's syndrome. Furthermore, the German version can standardize medical care of these patients. In particular it provides a means of participation in international research trials for this at risk population. PMID: 31399752 [PubMed - as supplied by publisher]
Late-life depression (LLD) is associated with significant public health burden, high disability, increased risk for cognitive decline and dementia, elevated suicide risk, and greater all-cause mortality rates.1 These negative outcomes are magnified by depression being a recurrent disorder, characterized by repeated episodes over a patient's lifetime.
Conclusion: Total SVD burden negatively associated with functional outcome at 3 months in patients with acute ischemic stroke and is superior to individual SVD feature in prediction of functional outcome. MRI-based assessment of total SVD burden is highly valuable in clinical management of stroke victims, and could help guide the allocation of resources to improve outcome.
Publication date: Available online 2 August 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Valentina Gumina, Claudia Colombrita, Claudia Fallini, Patrizia Bossolasco, Anna Maria Maraschi, John E. Landers, Vincenzo Silani, Antonia RattiAbstractThe RNA-binding protein TDP-43, associated to amyotrophic lateral sclerosis and frontotemporal dementia, regulates the alternative splicing of several genes, including the skipping of TNIK exon 15. TNIK, a genetic risk factor for schizophrenia and causative for intellectual disability, encodes for a Ser/Thr kinase regulating negatively F-actin d...
DiscussionExperiences of housing loss continued to be significantly associated with cognitive disability even six years after the disaster.
In this study we show, for the first time, significant alterations in cholesterol efflux capacity in adolescents throughout the range of BMI, a relationship between six circulating adipocyte-derived EVs microRNAs targeting ABCA1 and cholesterol efflux capacity, and in vitro alterations of cholesterol efflux in macrophages exposed to visceral adipose tissue adipocyte-derived EVs acquired from human subjects. These results suggest that adipocyte-derived EVs, and their microRNA content, may play a critical role in the early pathological development of ASCVD. Commentary on the Developing UK Government Position on Hea...
Abstract BACKGROUND: Although Shiatsu, a kind of complementary alternative medicine, was developed in Japan and is practiced around the world, no experimental studies on Shiatsu have been conducted. The aim of this study is to investigate the efficacy of Shiatsu therapy for chronic lower back pain. METHOD: We conducted a prospective, randomized, open, blinded-endpoint design study at St. Luke's International Hospital, Tokyo, Japan from 2015 to 2017. Patients with lower back pain for more than 12 weeks and a score of four or more on the Roland-Morris Disability Questionnaire (RMDQ) at baseline were included in...
This article summarizes the evidence for translation into action. PMID: 31327392 [PubMed - in process]
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