Biofunctional Effects of Thiohemiaminal-Type Dimeric Sesquiterpene Alkaloids from Nuphar Plants.

Biofunctional Effects of Thiohemiaminal-Type Dimeric Sesquiterpene Alkaloids from Nuphar Plants.
Chem Pharm Bull (Tokyo). 2019;67(7):666-674
Authors: Matsuda H, Nakamura S, Nakashima S, Fukaya M, Yoshikawa M
Abstract
Dimeric sesquiterpene thioalkaloids from the rhizomes of Nuphar pumilum exhibited immunosuppressive effects using a sheep erythrocyte plaque forming cell (PFC) assay, as well as an anti-metastasis effect, and rapid apoptosis-inducing effects in tumor cell lines. In particular, dimeric sesquiterpene thioalkaloids with a hydroxy group (6-hydroxythiobinupharidine, 6,6'-dihydroxythiobinupharidine, 6-hydroxythionuphlutine B) showed substantial effects, whereas dimeric sesquiterpene thioalkaloids lacking the hydroxy group (thiobinupharidine, thionuphlutine B, 6'-hydroxythionuphlutine B, neothiobinupharidine, thionuphlutine B β-sulfoxide, neothiobinupharidine β-sulfoxide) and monomeric sesquiterpene alkaloids (nupharidine, 7-epideoxynupharidine, nupharolutine) showed weak activity. In this review, we summarize our studies of the biofunctional effects of these alkaloids.
PMID: 31257322 [PubMed - in process]

Source: Chemical and Pharmaceutical Bulletin - July 3, 2019 Category: Drugs & Pharmacology Authors: Matsuda H, Nakamura S, Nakashima S, Fukaya M, Yoshikawa M Tags: Chem Pharm Bull (Tokyo) Source Type: research