Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia syndrome

Source: Cochrane Area: Evidence> Disease Focused Reviews Background Fibromyalgia syndrome (FMS) is a clinically well-defined chronic condition of unknown etiology characterized by chronic widespread pain that often co-exists with sleep disturbances, cognitive dysfunction and fatigue. Patients often report high disability levels and poor quality of life (QOL). Drug therapy focuses on reducing key symptoms and improving quality of life.   Objectives To assess the benefits and harms of serotonin and noradrenaline reuptake inhibitors (SNRIs) compared with placebo for treating FMS symptoms in adults.   Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL), (The Cochrane Library 2012, Issue 9), MEDLINE (1966 to September 2012), EMBASE (1980 to September 2012), www.clinicalstudyresults.org (U.S.-marketed pharmaceuticals) (to September 2012) and www.clinicaltrials.gov (to September 2012) for published and ongoing trials and examined the reference lists of reviewed ...
Source: NeLM - Disease Focused Reviews - Category: Internal Medicine Source Type: news

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Conclusion: The results of our study may suggest the presence of FM as a clinical sign of a more severe migraine. However, the long-term prospective studies including these group of patients are needed to understand the prognostic impact and importance of the comorbid FM in migraine. Abbreviations: FM: Fibromyalgia; MIDAS: Migraine Disability Assessment. PMID: 31221031 [PubMed - as supplied by publisher]
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
Publication date: June 2019Source: Neurophysiologie Clinique, Volume 49, Issue 3Author(s): Frédéric Viseux, Pascal Charpentier, Antoine LemaireFibromyalgia Syndrome (FMS) is a chronic and multi-faceted disease with an unknown aetiology. Clinical symptoms consisting of widespread pain, generalized muscular hypertonia, fatigue, sleep disturbances, impaired cognition and poor physical fitness compromise the autonomy, function and independence of these patients [1]. Postural control is affected and balance is impaired, leading to a greater risk and frequency of falls [2]. Pain in FMS may be associated with hypere...
Source: Neurophysiologie Clinique - Category: Neuroscience Source Type: research
Conclusion: These findings support the hypothesis that in FM a deteriorated function of cortical inhibition, indexed by a higher SICI parameter, a lower function of the DPMS, together with a higher level of BDNF indicate that FM has different pathological substrates from depression. They suggest that an up-regulation phenomenon of intracortical inhibitory networks associated with a disruption of the DPMS function occurs in FM. Introduction Major depressive disorder (MDD) and fibromyalgia (FM) present overlapped symptoms. Although the connection between these two disorders has not been elucidated yet, the disruption...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
CONCLUSIONS: At the moment, ozone therapy seems a treatment that, also because without any side effect, is possible to be proposed to patients with fibromyalgia that are not obtaining adequate results from other available treatments and it can be considered as complementary/integrative medicine. PMID: 30840304 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
This study explores experiences related to hearing loss and barriers to hearing health care among older Korean Americans.      Read more   Aging ...
Source: Johns Hopkins University and Health Systems Archive - Category: Nursing Source Type: news
Our definitions of pain matter more to researchers and people who like to philosophise about pain than to people experiencing pain. At the same time, definitions do matter because when the IASP definition of pain was first established, the distinction between the neurobiological underpinnings of pain – and the experience – was clear. And this matters because neurobiology is only part of the picture. (Chekka &Benzon, 2018; Cohen, Quintner &van Rysewyk, 2018; Reuter, Sienhold &Sytsma, 2018; Tesarz &Eich, 2017; Williams &Craig, 2016)The idea of “tribes” in pain and pain management i...
Source: HealthSkills Weblog - Category: Anesthesiology Authors: Tags: Pain conditions Professional topics diagnosis Education interprofessional lived experience silos social sociology tribes Source Type: blogs
Over the past few years I’ve been pondering the presumed gap between people living with pain and the people who “treat” or work with them.  Most of my readers will know that I live with widespread pain (aka fibromyalgia) or pain that is present in many parts of my body, and the associated other symptoms like DOMS that last for weeks not a day or two, and increased sensitivity to heat, cold, pressure, chilli, sound and so on. I first “came out” with my pain about 15 years ago: that is, I first disclosed to people I worked with that I had this weird ongoing pain – and finally joined...
Source: HealthSkills Weblog - Category: Anesthesiology Authors: Tags: Chronic pain Professional topics Research Therapeutic approaches inclusion inequality Source Type: blogs
CONCLUSIONS: Studies demonstrated no benefit of mirtazapine over placebo for pain relief of 50% or greater, PGIC, improvement of HRQoL of 20% or greater, or reduction of fatigue or negative mood. Clinically-relevant benefits were shown for pain relief of 30% or greater, reduction of mean pain intensity, and sleep problems. Somnolence, weight gain, and elevated alanine aminotransferase were more frequent with mirtazapine than placebo. The quality of evidence was low or very low, with two of three studies of questionable quality and issues over indirectness and risk of publication bias. On balance, any potential benefits of ...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
CONCLUSIONS: The update did not change the major findings of the previous review. Based on low- to very low-quality evidence, the SNRIs duloxetine and milnacipran provided no clinically relevant benefit over placebo in the frequency of pain relief of 50% or greater, but for patient's global impression to be much or very much improved and in the frequency of pain relief of 30% or greater there was a clinically relevant benefit. The SNRIs duloxetine and milnacipran provided no clinically relevant benefit over placebo in improving health-related quality of life and in reducing fatigue. Duloxetine and milnacipran did not signi...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Fibromyalgia (FM) is a chronic pain disorder of uncertain etiology characterized by widespread pain and numerous potential comorbidities including fatigue, disordered sleep, neurocognitive deficits, gastrointestinal distress, headache, anxiety, and depression.61 This symptomatology often presents in an unpredictable remitting/relapsing cycle that further detracts from patients' quality of life and results in significantly increased medical costs, health care utilization, and work-related disability.
Source: The Journal of Pain - Category: Materials Science Authors: Tags: Original Report Source Type: research
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