Biomarkers and their future use in clinical diagnostics and treatment

Biomarkers can be used to, at least partly, explain underlying mechanisms of a symptom or condition as in the article by Girisgen et al where both non-mono and mono-symptomatic bedwetting is the topic of investigation. During the last 3-4 decades there have been several studies showing that in the normal prepubertal child, the lowering of the nighttime diuresis is accompanied by a nightly increase in plasma arginine-vasopressin (AVP) with a peak in the first third of the night (2). Children with the polyuric type of bedwetting lack this increase on wet nights albeit if they have a dry night they may also display a nightly AVP increase.
Source: Journal of Pediatric Urology - Category: Urology & Nephrology Authors: Source Type: research