Physiological and pathological roles of kallikrein-related peptidases in the epidermis

Human kallikrein-related peptidases (KLKs) are differently expressed in many tissues, and exist as a subgroup of 15 serine proteases encoded by a tightly clustered multigene family on chromosome 19q13. 4 [1]. According to the comprehensive nomenclature, KLK1 is tissue kallikrein, and the other 14 KLKs (KLK2- KLK15) are kallikrein-related peptidases [2]. Five coding exons of the gene encode these proteases, with the second, third, and last exons containing the histidine, aspartate and serine residues of the catalytic triad [3].

Source: Journal of Dermatological Science - June 26, 2019 Category: Dermatology Authors: Mari Kishibe Tags: Invited Review Article Source Type: research