Cancers, Vol. 11, Pages 877: DNAM-1 and the TIGIT/PVRIG/TACTILE Axis: Novel Immune Checkpoints for Natural Killer Cell-Based Cancer Immunotherapy

Cancers, Vol. 11, Pages 877: DNAM-1 and the TIGIT/PVRIG/TACTILE Axis: Novel Immune Checkpoints for Natural Killer Cell-Based Cancer Immunotherapy Cancers doi: 10.3390/cancers11060877 Authors: Beatriz Sanchez-Correa Isabel Valhondo Fakhri Hassouneh Nelson Lopez-Sejas Alejandra Pera Juan M. Bergua Maria Jose Arcos Helena Bañas Ignacio Casas-Avilés Esther Durán Corona Alonso Rafael Solana Raquel Tarazona Natural killer (NK) cells are lymphocytes of the innate immune response characterized by their role in the destruction of tumor cells. Activation of NK cells depend on a fine balance between activating and inhibitory signals mediated by different receptors. In recent years, a family of paired receptors that interact with ligands of the Nectin/Nectin-like (Necl) family has attracted great interest. Two of these ligands, Necl-5 (usually termed CD155 or PVR) and Nectin-2 (CD112), frequently expressed on different types of tumor cells, are recognized by a group of receptors expressed on T and NK cells that exert opposite functions after interacting with their ligands. These receptors include DNAM-1 (CD226), TIGIT, TACTILE (CD96) and the recently described PVRIG. Whereas activation through DNAM-1 after recognition of CD155 or CD112 enhances NK cell-mediated cytotoxicity against a wide range of tumor cells, TIGIT recognition of these ligands exerts an inhibitory effect on NK cells by diminishing IFN-γ production, as well as NK cell-medi...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research