Comprehensive 4D robustness evaluation for pencil beam scanned proton plans
Due to anticipated clinical benefits, moving targets are potential future indications for pencil beam scanned proton therapy (PBS-PT). However, currently they are not widely treated at PBS-PT facilities due to dosimetric uncertainties caused by motion. We developed a method, the 4D robustness evaluation method (4DREM), to realistically and efficiently assess all possible events impacting PBS-PT treatments in the thorax. Using the 4DREM in large cohorts of lung and oesophageal cancer patients, it will become possible to illustrate, in clinical practice, how to trigger robustness settings for plan optimisation and to select and apply motion mitigation techniques.
Publication date: Available online 16 July 2019Source: The Annals of Thoracic SurgeryAuthor(s): Tamar Nobel, Jennifer Livschitz, Xin Xin Xing, Meier Hsu, Kay See Tan, Arianna Barbetta, Smita Sihag, David Jones, Daniela MolenaAbstractBackgroundThere are limited data regarding optimal surveillance after curative resection for esophageal cancer. Once disease recurrence is diagnosed, the prognosis is poor. The purpose of this paper was to characterize disease recurrence in patients with early esophageal adenocarcinoma (EAC).MethodsThere were 260 patients identified from a prospective institutional database with pathologic T1 a...
We report 2 elderly female patients with LPE who developed squamous cell carcinoma (SCC). Both underwent laparoscopic ischemic gastric preconditioning followed 2 weeks later by 3-field esophagectomy. Final pathological stages were carcinoma-in-situ and pT3N2, respectively. No adjuvant therapy was given. The patient with in-situ cancer has no evidence of recurrence at 24 months. The 2nd patient opted to follow up locally and died 8 months later. LPE should be closely monitored for malignant degeneration. Esophagectomy should be considered when malignancy is detected.
AbstractBackground.High‐grade neuroendocrine carcinomas are rare in the gastrointestinal tract. However, treatment patterns and outcomes have not been well described.Subjects, Materials, and Methods.The National Cancer Database was analyzed. The primary objective was to describe the clinical outcomes and identify prognostic factors. Univariate and multivariate analyses were done to identify factors associated with patient outcome.Results.A total of 1,861 patients were identified between 2004 and 2013. The mean age was 63 years (standard deviation ±13). The majority of the patients (78.1%) were non‐Hispanic white...
Conclusion: SEMS effectively reduced dysphagia in inoperable esophageal cancer. Better survival rates were observed in females than males.
CONCLUSIONS: The level of serum microRNA-1290 in ESCC patients increased significantly, and its expression level could reflect the progress of ESCC, suggesting that serum microRNA-1290 might be a useful diagnostic and prognostic marker of ESCC. PMID: 31306104 [PubMed - as supplied by publisher]
[Nation] Bomet has broken the cancer pattern in the country by recording oesophagus as the leading form of the killer disease in both male and female adults.
This article summarizes the milestones in the development of camrelizumab leading to this first approval for classical Hodgkin lymphoma.
This study suggests that proton beam therapy for esophageal cancer was not inferior in efficacy and had lower rates of toxicities in comparison to photon radiotherapy. Therefore, proton beam therapy can serve as an alternate treatment for patients with esophageal cancer.
Conditions: Esophagus Adenocarcinoma; Esophagus Squamous Cell Carcinoma; Gastroesophageal Junction Adenocarcinoma Intervention: Drug: Itraconazole Sponsor: Dallas VA Medical Center Recruiting
ConclusionsMutational profiling using NGS panels in advanced PC has yielded important potentially targetable genetic alterations. Larger studies are needed to identify commonly mutated genes in advanced PC patients. Development of novel therapies targeting these cellular pathways should be considered.