Who goes home on oxygen after a NICU stay?

Bronchopulmonary dysplasia (BPD) is the most common morbidity of extreme prematurity, and despite innovations in respiratory management, its incidence continues to rise. As an infant with BPD approaches term-equivalent gestation, one of the key questions is whether supplemental oxygen will be needed at home. Clinicians are required to balance the benefits of earlier discharge with the challenges of introducing medical equipment and monitoring into the household. These problems are made more difficult by the lack of knowledge on the benefits and risks of supplemental oxygen use beyond the birth hospitalization.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: The Editors' Perspectives Source Type: research

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Pulmonary hypertension secondary to bronchopulmonary dysplasia (BPD-PH) represents a major complication of BPD in extremely preterm infants for which there are currently no safe and effective interventions. The abundance of interleukin-1 (IL-1) is strongly correlated with the severity and long-term outcome of BPD infants and we have previously shown that IL-1 receptor antagonist (IL-1Ra) protects against murine BPD; therefore, we hypothesized that IL 1Ra may also be effective against BPD-PH. We employed daily injections of IL-1Ra in a murine model in which BPD/BPD-PH was induced by antenatal LPS and postnatal hyperoxia of ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
The objective of our study was to determine whether systemic inflammatory stress induces IL-1α expression in the neonatal lung, and if so, whether this expression is mediated by innate immune NFκB signaling. We found that endotoxemia induced IL-1α expression during the saccular stage of neonatal lung development and was not present in the other neonatal organs or the adult lung. This IL-1α expression was dependent upon sustained pulmonary NFκB activation, which was specific to the neonatal lung. Using in vivo and in vitro approaches, we found that pharmacologic and genetic inhibition of NF&kap...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
To investigate the hematological features of infants with bronchopulmonary dysplasia (BPD) and their relationships with clinical severity.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Original Article Source Type: research
We thank Dr Hansen for pointing out this rare phenomenon in infants, but would like to caution against drawing conclusions. Dr Hansen describes his own child with tracheomalacia whose clinical condition worsened with inhaled nitric oxide (iNO) and improved after withdrawal of the same. He postulates loss of tracheal tone with iNO. We have also observed “airway spasm,” though extremely rarely and only in infants with either Down syndrome or with severe bronchopulmonary dysplasia (BPD) and suspected tracheobronchomalacia.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: LETTER TO THE EDITOR Source Type: research
CONCLUSIONS: Based on the evidence from randomised controlled trials to date, inositol supplementation does not result in important reductions in the rates of infant deaths, ROP stage 3 or higher, type 1 ROP, IVH grades 3 or 4, BPD, NEC, or sepsis. These conclusions are based mainly on two recent randomised controlled trials in neonates less than 30 weeks' postmenstrual age (N = 760), the most vulnerable population. Currently inositol supplementation should not be routinely instituted as part of the nutritional management of preterm infants with or without RDS. It is important that infants who have been enrolled in the tri...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
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Source: Journal of Maternal-Fetal and Neonatal Medicine - Category: Perinatology & Neonatology Authors: Source Type: research
Authors: Wongnophirun A, Khuwuthyakorn V, Tantiprabha W, Wiwatwongwana A Abstract Background: Poor postnatal weight gain has been associated with low serum IGF-1, a key factor in the pathogenesis of retinopathy of prematurity (ROP). Aim: To investigate an association between relative weight gain (RWG) and severe ROP in very low-birthweight (VLBW) Thai infants. Methods: The medical records of VLBW infants who were admitted to the neonatal intensive care unit in Chiang Mai University Hospital from June 2014 to December 2016 and screened for ROP were reviewed. RWG and total calorie intake (TCI) in the 2nd, 4rth and 6t...
Source: Paediatrics and international child health - Category: Pediatrics Tags: Paediatr Int Child Health Source Type: research
Premature birth is a growing and serious public health problem affecting more than one of every ten infants worldwide. Bronchopulmonary dysplasia (BPD) is the most common neonatal morbidity associated with pre...
Source: BMC Pediatrics - Category: Pediatrics Authors: Tags: Study protocol Source Type: research
Conclusions: The majority of conservatively treated late PDAs closed spontaneously or decreased in size.PDA surgery was not associated with severe adverse clinical outcomes.Neonatology
Source: Neonatology - Category: Perinatology & Neonatology Source Type: research
Publication date: August 2019Source: Research in Developmental Disabilities, Volume 91Author(s): Maria Lithoxopoulou, Dimitrios Rallis, Helen Christou, Evanthia Goutsiou, Agoritsa Varaklioti, Paraskevi Karagianni, Christos Tsakalidis, Philip Domeyer, Georgia Kuriakeli, Vasiliki SoubasiAbstractBackgroundAdequate nutrition is essential for optimal neurodevelopment to preterm infants. Our aim was to evaluate the impact of caloric deprivation on Bayley-III scales performance at 18–24 months of corrected age, in a cohort of preterm infants.MethodsWe prospectively enrolled infants with gestational age
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
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