What can copeptin tell us in patients with autosomal dominant polycystic disease?
Vasopressin is known to contribute to disease progression in autosomal dominant polycystic disease (ADPKD) by its influence on cyclic adenosine monophosphate that directly promotes cyst growth. In addition, vasopressin probably contributes to progression by inducing glomerular hyperfiltration as shown in other forms of chronic kidney diseases. The measurement of plasma copeptin, a marker of vasopressin secretion, could help identify patients at higher risk of fast progression and those expected to benefit the most from vasopressin V2 receptor blockade.
ConclusionsRemission of type 2 diabetes 5 years after bariatric surgery was associated with improvements in albuminuria and stabilized prognostic risk for CKD, but not with eGFR. Lower kidney function and greater prognostic risk at the time of bariatric surgery was linked to a lower likelihood of diabetes remission. These results highlight the need to identify the mechanisms through which bariatric surgery may delay the long-term progression of CKD in type 2 diabetes.
Publication date: September 2019Source: IJC Heart &Vasculature, Volume 24Author(s): Ming-Yen Ng, Pui Min Yap, Kai Hang Yiu
Introduction: Sarcopenia is a risk factor associated with chronic kidney disease (CDK). The aim of the following study was to evaluate muscle mass and its function in patients with MRC in conservative therapy.
AbstractBackgroundChronic kidney disease (CKD) has become one of the most frequent non-infectious comorbidities in the aging HIV-infected population on long-standing combination antiretroviral therapy (cART).MethodsWe conducted a retrospective, cross-sectional study including HIV-infected adult patients attending our HIV outpatient clinic during the years 2017 and 2018 to assess prevalence and associated risk factors of CKD. Estimated glomerular filtration rate (eGFR) was measured by Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation. CKD was diagnosed and classified according to the National Kidney Found...
Authors: Gali B, Eyawo O, Hull MW, Samji H, Zhang W, Sereda P, Lima VD, McGrail K, Montaner JSG, Hogg RS, Moore D, COAST Study Team Abstract Objective: To characterize the incidence of select chronic comorbidities in the era of modern (pre-integrase inhibitor) highly active antiretroviral therapy (HAART) in British Columbia, Canada. Methods: We used data from the Comparative Outcomes And Service Utilization Trends (COAST) study, a population-based cohort study of people living with HIV (PLWH), to determine incidence rates of six key chronic diseases among PLWH receiving HAART in BC from 2000 to 2012. The selected d...
Sanchis et al.1 reported interesting data on the association between vascular calcification and arterial inflammaging in children with advanced chronic kidney disease. We agree that uremic children are a potentially ideal model for studying accelerated cellular senescence, but the authors do not differentiat e between those on hemodialysis and those on peritoneal dialysis therapy. Peritoneal dialysis is known to be characterized by a generally superior biocompatibility compared with hemodialysis.
The study by Wang et al.1 revealed a comprehensive description of the burden of chronic kidney disease and end-stage kidney disease in China. The study estimated that there were approximately 553,000 hemodialysis patients and 55,000 peritoneal dialysis patients in China in 2015. The median annual overall cost for each peritoneal dialysis and hemodialysis patient was 73,266 and 87,125 renminbi, respectively.1 According to these data, the total medical expenditure for dialysis patients would have been 40–50 billion renminbi in 2015, but it was reported as 429 million renminbi.
The epidemiology and pathology of kidney disease is still unknown in large parts of the world that are burdened with high rates of chronic kidney disease. In part, this is due to inability to adequately process and interpret kidney biopsies. Proper interpretation of kidney biopsies requires integration of light microscopy (LM), immunofluorescence microscopy (IF) or immunohistochemistry studies, and electron microscopy (EM) findings with clinical and laboratory data that can also provide prognostic information leading to an appropriate treatment.
Individuals with diabetes have remarkably high rates of cardiovascular morbidity and mortality. However, the incremental cardiovascular risk in diabetes is heterogeneous and has often been related to renal inv...
ConclusionsOur prospective study performed in a real-world setting showed a high immunogenicity and safety of HBV-AS04 vaccine in patients with CKD not yet on maintenance dialysis. Studies provided with longer follow-ups are under way to assess the durability of seroprotection in responders.