Maternal and Perinatal Outcomes in Pregnant Women with Cystic Fibrosis
Abstract Objectives To assess the perinatal and maternal outcomes of pregnant women with cystic fibrosis (CF) and severe lung impairment. Methods This was a series of cases aiming to review the maternal and fetal outcomes in cases of singleton pregnant women with a diagnosis of CF. We have included all of the cases of singleton pregnancy in patients with CF who were followed-up at the obstetrics department of the Medical School of the Universidade de S ão Paulo, between 2003 and 2016. The exclusion criteria were the unattainability of the medical records of the patient, and delivery at other institutions. A forced expiratory volume in 1 second
To investigate how poor pre-gestational pulmonary function influenced pregnancy outcome and clinical status evolution in women with cystic fibrosis.
Conclusion: There are maternal and neonatal conditions that can affect heel prick test results, and therefore, their investigation is essential, aiming to guide measures that promote mother and child health and consolidate neonatal screening in this population.
PMID: 31240725 [PubMed - as supplied by publisher]
In conclusion, our study demonstrated that H2S inhibits the transepithelial anion secretion of early pregnant mouse endometrial epithelium via blockade of CFTR, contributing to the preparation for embryo implantation.
Our objective was to explore knowledge, attitudes, and beliefs about pregnancy and contraceptive decision-making among reproductive-aged women with cystic fibrosis.
Publication date: Available online 7 May 2019Source: Reproductive BioMedicine OnlineAuthor(s): Anna Tournier, Marlène Murris, Anne Prevotat, Annlyse Fanton, Célia Bettiol, Jean ParinaudAbstractEven though the impact of cystic fibrosis (CF) on male fertility is well known, very few studies have investigated its effect on women fertility. In order to evaluate the fertility status of women with cystic fibrosis a questionnaire was sent to 220 women with cystic fibrosis. The questions concerned their desire to become a parent, achievement or not of a pregnancy, the time to became pregnant, the way to obtain pregna...
In this study, we exposed apically well-differentiated human NECs cultured at the ALI to the related flaviviruses ZIKV, JEV, WNV, and Usutu virus (USUV). We selected these viruses due to the recent increasing evidences of potential threat to humans (Cadar et al., 2017; Simonin et al., 2018). We show that NECs are particularly susceptible to JEV and WNV infection and to other flaviviruses included in this study. Infection with each virus led to shedding of infectious virus particles through the apical and basolateral surfaces and triggered host mechanisms at the level of inflammatory and antiviral mediators. Given...