Genetic diversity of HLA system in three populations from Guanajuato, Mexico: Guanajuato City, Le ón and rural Guanajuato.

Genetic diversity of HLA system in three populations from Guanajuato, Mexico: Guanajuato City, León and rural Guanajuato. Hum Immunol. 2019 Jun 14;: Authors: Pantoja-Torres JA, Barquera R, Ballesteros-Romero M, Bravo-Acevedo A, Arrieta-Bolaños E, Montiel-Hernández GD, Clayton S, Rodríguez-Rodríguez LI, Hernández-Zaragoza DI, Goné-Vázquez I, Escobedo-Ruíz A, García-Arias VE, Arellano-Prado FP, Rodríguez-López ME, Sánchez-Fernández MGJ, Sandoval-Sandoval MJ, Gómez-Navarro B, Zúñiga J, Yunis EJ, Bekker-Méndez C, Granados J Abstract We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 262 Mexicans from the state of Guanajuato living in the cities of Guanajuato (N = 78), León (N = 22) and rural communities (N = 162), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes found in the state of Guanajuato include 12 Native American and three European haplotypes. Admixture estimates revealed that the main genetic components in the state of Guanajuato are Native American (50.64 ± 2.11% by ML, 43.35% of Native American haplotypes) and European (44.14 ± 1.14% by ML; 39.35% of European haplotypes), while African genetic component is less apparent (5.22 ± 2.08% by ML; 8.36% of African haplotypes). PMID: 31204089 [PubMed - as supplied by publisher]
Source: Human Immunology - Category: Allergy & Immunology Authors: Tags: Hum Immunol Source Type: research