In HIV primary infection, early cART reduced γδ T cell activation but failed to restore their polyfunctionality.

In conclusion, during primary HIV infection, the baseline Vδ1 T cell activation is correlated with immune reconstitution potential. Moreover, an altered γδ polyfunctional profile occurred, persisting also after cART. Further studies are needed to understand whether a longer treatment of primary infection may increase γδ T cell functionality. This article is protected by copyright. All rights reserved.
PMID: 31206171 [PubMed - as supplied by publisher]

Source: Immunology - June 16, 2019 Category: Allergy & Immunology Authors: Casetti R, Sacchi A, Bordoni V, Grassi G, Cimini E, Besi F, Pinnetti C, Mondi A, Antinori A, Agrati C Tags: Immunology Source Type: research