Optimal Timing of Total Gastrectomy to Prevent Diffuse Gastric Cancer in Individuals with Pathogenic Variants in CDH1

Carriers of pathogenic variants in CDH1 have a high risk of hereditary diffuse gastric cancer (HDGC). Guidelines recommend prophylactic total gastrectomy (PTG) at age 20 –30 years, although there is controversy over the optimal age. We developed a simulation model to analyze the effects of PTG at different ages on quality-adjusted life-years (QALYs), cancer mortality, and life expectancy.

Source: Clinical Gastroenterology and Hepatology - June 16, 2019 Category: Gastroenterology Authors: Monika Laszkowska, Elisabeth Silver, Beth Schrope, Fay Kastrinos, Timothy C. Wang, Chin Hur Source Type: research