Do interactions between Protein and Phospholipids influence the release behavior from lipid-based exenatide depot systems?

In conclusion, erosion of the VPG matrix and membrane permeability of the drug are the major parameters influencing the release of exenatide from VPGs of POPC-POPG, whereas drug binding to the membranes had a minor effect only.
PMID: 31195130 [PubMed - as supplied by publisher]

Source: European Journal of Pharmaceutics and Biopharmaceutics - June 9, 2019 Category: Drugs & Pharmacology Authors: Breitsamer M, Stulz A, Heerklotz HH, Winter G Tags: Eur J Pharm Biopharm Source Type: research