Mal-deficiency impairs the tolerogenicity of dendritic cell of patients with allergic rhinitis.

In conclusion, Mal plays a critical role in the maintenance of decDC's immune tolerogenic function. The absence or insufficient Mal signal impairs decDC's tolerogenic property. Reconstitution of Mal in AR decDCs can restore the immune tolerogenic capacity, which may have translational potential in the treatment of AR and other allergic diseases.
PMID: 31196568 [PubMed - as supplied by publisher]

Source: Cellular Immunology - June 5, 2019 Category: Allergy & Immunology Authors: Shao JB, Yang G, Zhang YY, Ma F, Luo XQ, Mo LH, Liu ZQ, Liao WJ, Qiu QH, Li DC, Yang LT, Zhang XW, Liu DB, Yang PC Tags: Cell Immunol Source Type: research