Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation

To identify a synovial fluid (SF) biomarker profile characteristic of individuals with an inflammatory osteoarthritis (OA) endotype.
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research

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Publication date: Available online 19 August 2019Source: World Journal of Acupuncture - MoxibustionAuthor(s): Xiu-feng GU, Fei WANG, Yan-yan ZHANGAbstractObjectiveTo compare the therapeutic effect difference among dog-day moxibustion on herbs, ordinary moxibution and routine western medication in treating knee-joint osteoarthritis of yang deficiency and congealing cold type.MethodsA total of 90 patients with knee-joint osteoarthritis of yang deficiency and congealing cold type were divided into dog-day moxibustion group, ordinary moxibution group and western medication group according to the registration order, and there w...
Source: World Journal of Acupuncture Moxibustion - Category: Complementary Medicine Source Type: research
ConclusionPain improved considerably in both arms over 60 months. While ITT analysis revealed no statistically significant differences in TKR use, greater TKR utilization in those receiving APM merits further study.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
The objective of this review is to summarize the molecular mechanisms of inflammation and oxidative stress activated by Cd at the bone level, particularly in osteoporosis, RA, and OA. Cadmium can increase bone resorption, affect the activity of osteoclasts and calcium (Ca) absorption, and impair kidney function, which favors the development of osteoporosis. In the case of RA, Cd interferes with the activity of antioxidant proteins, like superoxide dismutase (SOD) and catalase (CAT). It also promotes an inflammatory state, inducing the process of citrullination, which affects the proteins of immune response. On the other ha...
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research
The United States is in an obesity epidemic. Obesity has multiple common comorbid conditions, including lower extremity arthritis. We sought to examine the course of treatment for a population with body mass index (BMI) ≥ 40 kg/m2 and osteoarthritis (OA) of the hip or knee. We investigated decision criteria that influenced arthroplasty surgeons to recommend non-operative management versus total joint arthroplasty (TJA). For those patients who ultimately received TJA, we compared outcomes in this population to tho se with BMI
Source: The Journal of Arthroplasty - Category: Orthopaedics Authors: Source Type: research
Authors: Safran MR, Bedi A, Byrd JWT, Guanche CA, Ilizaliturri V, Lynch TS, Martin HD, Matsuda DK, McCarthy JC, Philippon MJ, Sampson TG, Suarez-Ahedo C Abstract Hip arthroscopy is one of the most rapidly growing areas in orthopaedic surgery because of increased awareness of nonarthritic hip pathologies, advanced imaging modalities, and advanced techniques to reproducibly manage nonarthritic hip pathologies within a deep soft-tissue envelope and a constrained joint. In addition, more academic medical centers are providing residents with education on hip arthroscopy, and many hip preservation fellowships and courses...
Source: Instructional Course Lectures - Category: Orthopaedics Tags: Instr Course Lect Source Type: research
Authors: Murthi AM, Cox RM, Strelzow JA, Athwal GS, Tashjian RZ, Abboud JA Abstract The management of glenohumeral arthritis in young patients is a challenge given the higher demand for use of the arms, need for longer implant survivorship, and higher postoperative expectations in this patient population. Shoulder arthroplasty is an excellent treatment option for elderly patients with glenohumeral arthritis because this patient population does not have demands as high as those of younger patients with glenohumeral arthritis. Common causes of glenohumeral arthritis in young patients include chondrolysis, inflammator...
Source: Instructional Course Lectures - Category: Orthopaedics Tags: Instr Course Lect Source Type: research
ConclusionReported cases of PTRCT and its surgical repair have both increased substantially over time. Approximately 11.70% of patients with PTRCT undergo either open or arthroscopic procedure as a means of surgical repair. With the growing popularity of arthroscopic procedures for rotator cuff repair, further investigation should be performed to analyze trends and risk factors for PTRCT, a seemingly underrepresented orthopedic condition.
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research
Condition:   Knee Osteoarthritis Interventions:   Other: Multiprofessional treatment and Educational Program Associated (EPA+C+BCAA) with supplementation of creatine and BCAA.;   Other: Multiprofessional treatment and Educational Program Associated (EPA+C) with supplementation of creatine only. Sponsor:   University of Sao Paulo General Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 12 August 2019Source: Journal of OrthopaedicsAuthor(s): Tetsutaro Abe, Nobuhiro Kaku, Tomonori Tabata, Hiroaki Tagomori, Hiroshi TsumuraAbstractWe aimed to clarify the possibility of using bipolar hip arthroplasty (BHA) for degenerative diseases by examining long-term results postoperatively in 336 hips. Patients’ average age was 61.0 years (range, 34–88 years), and the average follow-up period was 12.5 years (range, 5.0–27.3 years). The 5-year, 10-year, and 20-year Kaplan Meier survival rates (end point: revision) were 92.1%, 81.8%, and 20.1% in the osteoarthritis group...
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research
Isolated patellofemoral joint (PFJ) arthritis has been identified in 10% of the population presenting with symptomatic knee osteoarthritis. Patient selection is important in order to improve survivorship following PF arthroplasty. The purpose of this study was to compare the use of a preoperative bone scan versus an MRI to identify the patient with isolated PF arthritis.
Source: The Journal of Arthroplasty - Category: Orthopaedics Authors: Source Type: research
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