Cytotoxic abietane and kaurane diterpenoids from Celastrus orbiculatus

AbstractCelastrus orbiculatus is a medicinal plant belonging to the Celastraceae family. In this survey on the secondary metabolites of plants for obtaining antitumor substances, the chemical constituents of the stems ofC. orbiculatus were investigated. Nortriptonoterpene (1), a new C19-norabietane diterpenoid, together with six other known abietane-type diterpenoids (2–7) and five known kaurane-type diterpenoids (8–12) were isolated and identified from the EtOAc extract ofC. orbiculatus. Their structures were elucidated on the basis of extensive spectroscopic methods, including UV, IR, HR-ESI –MS, ECD, and NMR experiments, and by comparison with literature data. Compound1 is a new C19-norabietane diterpenoid with 19 carbons. All compounds except for10 and11 were isolated fromC. orbiculatus for the first time. The NMR data of9 were reported for the first time. Compounds1,7 and11 showed cytotoxicities against SGC-7901 with IC50 values of 63.2, 80.9 and 56.7  μM, respectively.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research