A Return Journey: Hope and Strength in the Aftermath of Alzheimer ’s

AbstractSue Petrovski ’s short book,A Return Journey: Hope and Strength in the Aftermath of Alzheimer ’s, is a collection of personal stories as she and her husband cared for her mother during the course of the disease as well as the shared stories of others.A Return Journey provides an insider ’s view of the challenges of caring for those with Alzheimer’s and is useful for current and future caregivers as well as those who are studying and working in the health professions.
Source: Journal of Bioethical Inquiry - Category: Medical Ethics Source Type: research

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CONCLUSIONS: Our results suggest that T1AM and TAAR1 are part of an endogenous system that can be modulated to prevent synaptic and behavioral deficits associated with Aβ-related toxicity. PMID: 31709926 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
CONCLUSIONS: Brexpiprazole 2 mg/day has the potential to be efficacious, safe, and well tolerated in the treatment of AAD. PMID: 31708380 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
(Alzheimer's Association) 5-year grant aimed at identifying evidence-based strategies to enhance care and support for individuals with dementia and their care partners.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Alzheimer’s disease (AD) is a neurodegenerative disease and the main cause of dementia. Its major symptom is memory loss, which is a result of neuronal cell death, which is accompanied by neuroinflammation. Some studies indicate the overactivation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mechanistic target of rapamycin (mTOR) pathway in this disease, being, thus, a potential target for pharmacological treatment. Here, we used a transgenic mouse model of AD that expresses a mutant amyloid-β precursor protein (T41 mice) to investigate the effects of dactolisib (alternative name: NVP-BEZ23...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
This article presents the original descriptions of some recent physics mechanisms (based on the thermodynamic, kinetic, and quantum tunnel effects) providing stable 2H/1H isotope fractionation, leading to the accumulation of particular isotopic forms in intra- or intercellular space, including the molecular effects of deuterium interaction with 18O/17O/16O, 15N/14N, 13C/12C, and other stable biogenic isotopes. These effects were observed mainly at the organelle (mitochondria) and cell levels. A new hypothesis for heavy nonradioactive isotope fractionation in living systems via neutron effect realization is discussed. The c...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
pirat Chaikuad Conrad Kunick Since hyperactivity of the protein kinase DYRK1A is linked to several neurodegenerative disorders, DYRK1A inhibitors have been suggested as potential therapeutics for Down syndrome and Alzheimer’s disease. Most published inhibitors to date suffer from low selectivity against related kinases or from unfavorable physicochemical properties. In order to identify DYRK1A inhibitors with improved properties, a series of new chemicals based on [b]-annulated halogenated indoles were designed, synthesized, and evaluated for biological activity. Analysis of crystal structures revealed a ty...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Edward B. Lee, MD, PhDFrom time to time on Neuropathology Blog, we profile a prominent neuropathologist. In the past, we've featured the likes of Craig Horbinski, Roger McLendon,Jan Leestma,Karra Jones,Areli Cuevas-Ocampo,Michael Punsoni,andPJ Cimino, among others. Today we feature Eddie Lee, MD, PhD. Dr. Lee is an assistant professor in the pathology department at the University of Pennsylvania. Here's a Q&A with the illustrious Dr. Lee:1. Why did you decide to become a neuropathologist?The three major topics that dominate Alzheimer ’s disease research are amyloid, tau, and neuroinflammation.&nbs...
Source: neuropathology blog - Category: Radiology Tags: neuropathologists Source Type: blogs
Keeping blood pressure in check may lower the risk of Alzheimer ’s disease and other forms of dementia.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Alzheimer ' s Disease Blood Pressure Dementia Source Type: news
This study measured stimulus-evoked brain tissue oxygenation changes in a mouse model of Alzheimer disease (AD) and further explored the influence of exercise and angiotensin II-induced hypertension on these changes. In vivo two-photon phosphorescence lifetime microscopy was used to investigate local changes in brain tissue oxygenation following whisker stimulation. During rest periods, PO2 values close to the arteriolar wall were lower in the AD groups and the PO2 spatial decay as a function of distance to arteriole was increased by hypertension. During stimulation, tissue PO2 response had a similar spatial dependence acr...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
In conclusion, melatonin ameliorates memory deficits in STZ-induced hyperglycemia rats by restoring insulin signaling pathway which is independent of its effects on blood glucose and insulin levels. Thus, melatonin might be a therapeutic option for helping patients suffering from diabetes and contributed to Alzheimer's disease.
Source: Neurochemistry International - Category: Neuroscience Source Type: research
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