Analysis of Feedforward Mechanisms of Multiwhisker Receptive Field Generation in a Model of the Rat Barrel Cortex

Publication date: Available online 12 June 2019Source: Journal of Theoretical BiologyAuthor(s): Mainak PatelAbstractThere is substantial anatomical segregation in the organization of the rodent barrel system – each whisker on the mystacial pad sends input to TC cells within a dedicated thalamic barreloid, which in turn innervates a corresponding cortical barrel, and RS cells within a barrel respond primarily to deflections of the corresponding whisker at the beginning of the dedicated transmission line (the principal whisker, PW). However, it is also well-established that barrel cells exhibit multiwhisker receptive fields (RFs), and display lower amplitude, longer latency responses to deflections of non-PWs (or adjacent whiskers, AWs). There is considerable controversy regarding the origin of such multiwhisker RFs; three possibilities include: (i) TC cells within a barreloid respond to multiple whiskers, and barrel RS cells simply inherit multiwhisker responses from their aligned barreloid; (ii) TC cells respond only to the PW, but individual barreloids innervate multiple barrels; (iii) multiwhisker responses of barrel cells arise from lateral corticocortical (barrel-to-barrel) synaptic transmission. Ablation studies attempting to pinpoint the source of RS cell AW responses are often contradictory (though experimental work tends to suggest possibilities (i) or (iii) to be most plausible), and hence it is important to carefully evaluate these hypotheses in terms of available...

Source: Journal of Theoretical Biology - June 12, 2019 Category: Biology Source Type: research