Caspase-8 promotes c-Rel-dependent inflammatory cytokine expression and resistance against Toxoplasma gondii [Immunology and Inflammation]

Caspase-8 is a key integrator of cell survival and cell death decisions during infection and inflammation. Following engagement of tumor necrosis factor superfamily receptors or certain Toll-like receptors (TLRs), caspase-8 initiates cell-extrinsic apoptosis while inhibiting RIPK3-dependent programmed necrosis. In addition, caspase-8 has an important, albeit less well understood, role in...

Source: Proceedings of the National Academy of Sciences - June 10, 2019 Category: Science Authors: Alexandra A. DeLaney, Corbett T. Berry, David A. Christian, Andrew Hart, Elisabet Bjanes, Meghan A. Wynosky-Dolfi, Xinyuan Li, Bart Tummers, Irina A. Udalova, Youhai H. Chen, Uri Hershberg, Bruce D. Freedman, Christopher A. Hunter, Igor E. Brodsky Tags: PNAS Plus Source Type: research