Skin metabolism phase I and phase II enzymes in native and reconstructed human skin: a short review.

Skin metabolism phase I and phase II enzymes in native and reconstructed human skin: a short review.
Drug Discov Today. 2019 Jun 06;:
Authors: Kazem S, Linssen EC, Gibbs S
Abstract
Understanding skin metabolism is important when considering drug discovery and safety assessment. This review compares xenobiotic skin metabolism in ex vivo skin to reconstructed human skin and reconstructed human epidermis models, concentrating on phase I and phase II enzymes. Reports on phase I enzymes are more abundant than for phase II enzymes with mRNA and protein expression far more reported than enzyme activity. Almost all of the xenobiotic metabolizing enzymes detected in human skin are also present in liver. However, in general the relative levels are lower in skin than in liver and fewer enzymes are reported.
PMID: 31176740 [PubMed - as supplied by publisher]

Source: Drug Discovery Today - June 5, 2019 Category: Drugs & Pharmacology Authors: Kazem S, Linssen EC, Gibbs S Tags: Drug Discov Today Source Type: research