Allele-Specific siRNA Silencing for the Common Keratin 12 Founder Mutation in Meesmann Epithelial Corneal Dystrophy [Cornea]

Conclusions.
A potent allele-specific siRNA against the K12 Arg135Thr mutation was identified. In combination with efficient eyedrop formulation delivery, this would represent a personalized medicine approach, aimed at preventing the pathology associated with MECD and other ocular surface pathologies with dominant-negative or gain-of-function pathomechanisms.

Source: Investigative Ophthalmology - January 17, 2013 Category: Opthalmology Authors: Allen, E. H. A., Atkinson, S. D., Liao, H., Moore, J. E., Leslie Pedrioli, D. M., Smith, F. J. D., McLean, W. H. I., Moore, C. B. T. Tags: Cornea Source Type: research