MammaPrint and BluePrint Molecular Diagnostics using targeted RNA Next-Generation Sequencing technology

Next-generation DNA sequencing (NGS) is rapidly becoming an indispensable tool for genome-directed cancer diagnostics, but next-generation RNA sequencing (RNA-seq) is currently not standardly used in clinical diagnostics for expression assessment. However, multi-gene RNA diagnostic assays are used increasingly in the routine diagnosis of early stage breast cancer. Two of the most widely used tests are currently available only as a central laboratory service, which limits their clinical use. We evaluated the use of RNA-seq as a de-centralized methodology to perform such tests.
Source: Journal of Molecular Diagnostics - Category: Pathology Authors: Tags: Regular Article Source Type: research

Related Links:

Source: BMJ Comments - Category: General Medicine Source Type: forums
Publication date: Available online 20 October 2019Source: The LancetAuthor(s): Daniel I Sessler, Lijian Pei, Yuguang Huang, Edith Fleischmann, Peter Marhofer, Andrea Kurz, Douglas B Mayers, Tanja A Meyer-Treschan, Martin Grady, Ern Yu Tan, Sabry Ayad, Edward J Mascha, Donal J Buggy, Gang Tan, Zhiyong Zhang, Helen Keane, Maurice Stokes, Oliver Zotti, Michael Gnant, Silvia Perez-ProttoSummaryBackgroundThree perioperative factors impair host defence against recurrence during cancer surgery: the surgical stress response, use of volatile anaesthetic, and opioids for analgesia. All factors are ameliorated by regional anaesthesia...
Source: The Lancet - Category: General Medicine Source Type: research
ConclusionsWhile patient symptoms are important predictors of patient well-being, subjective appraisals of the stressfulness of symptoms, and of patients ’ self-efficacy in managing symptoms, are also key factors. The findings suggest the utility of a stress process model in understanding well-being in breast cancer patients, and point to the potential value of targeting patient appraisals as well as symptoms to improve psychological well-being and quality of life.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
ConclusionsThe study suggests that quality of life and body image are temporarily impaired due to RT. Around one third of patients score their long-term AO as unfavourable. These results should be discussed with the patient and could help in the decision making of the treatment plan and in the clarification of the patient ’s expectations.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
Women seek out breast cancer screening at different rates as they grow older...Read more on AuntMinnie.comRelated Reading: DBT finds more cancers of all types than FFDM UCSF launches AI center for medical imaging Women born outside U.S. less likely to undergo mammography Image processing shows potential to reduce MBI dose Patient navigation boosts women's screening compliance
Source: Headlines - Category: Radiology Source Type: news
Condition:   Breast Cancer Stage IV Intervention:   Sponsor:   Hellenic Cooperative Oncology Group Active, not recruiting
Source: - Category: Research Source Type: clinical trials
Condition:   Breast Cancer Female Intervention:   Biological: blood samples collection Sponsor:   Centre Jean Perrin Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Condition:   Breast Tumors Intervention:   Drug: DS-8201a Sponsors:   UNICANCER;   Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Condition:   Breast Cancer Interventions:   Drug: nivolumab;   Drug: ipilimumab;   Drug: nab-paclitaxel Sponsor:   Bristol-Myers Squibb Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Americans consume about 150 pounds of milk and eat nearly 40 pounds of cheese and 20 pounds of ice cream per person per year, according to data from the Department of Agriculture. Yogurt and butter intakes are lower, but growing. But should the dairy we’re consuming be low-fat or full-fat? That debate has become increasingly divisive, and for good reason: not all dairy is created equal. Dairy fat and cardiovascular disease Some of the most substantial dairy research has been done in the context of the Dietary Approaches to Stop Hypertension (DASH) diet, which has been shown, among other benefits, to reduce blood pres...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Cancer Diet and Weight Loss Health Healthy Eating Heart Health Source Type: blogs
More News: Breast Cancer | Cancer | Cancer & Oncology | Genetics | Laboratory Medicine | Pathology