MammaPrint and BluePrint Molecular Diagnostics using targeted RNA Next-Generation Sequencing technology
Next-generation DNA sequencing (NGS) is rapidly becoming an indispensable tool for genome-directed cancer diagnostics, but next-generation RNA sequencing (RNA-seq) is currently not standardly used in clinical diagnostics for expression assessment. However, multi-gene RNA diagnostic assays are used increasingly in the routine diagnosis of early stage breast cancer. Two of the most widely used tests are currently available only as a central laboratory service, which limits their clinical use. We evaluated the use of RNA-seq as a de-centralized methodology to perform such tests.
Source: Journal of Molecular Diagnostics - Category: Pathology Authors: Lorenza Mittempergher, Leonie JMJ. Delahaye, Anke Witteveen, Jacob B. Spangler, Fariet Hassenmahomed, Sammy Mee, Soufiane Mahmoudi, Jiang Chen, Simon Bao, Mireille HJ. Snel, Sandra Leidelmeijer, Naomi Besseling, Anne Bergstrom Lucas, Carlos Pab ón-Peña, Tags: Regular Article Source Type: research