Gene responsible for increased severity of influenza in Chinese populations

Researchers have found a genetic variant which explains why Chinese populations may be more vulnerable to Swine Flu.
Source: Medical Research Council Research News - Category: Research Source Type: news

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Publication date: Available online 14 March 2019Source: Preventive Veterinary MedicineAuthor(s): Y. Li, J. Edwards, Y. Wang, G. Zhang, C. Cai, M. Zhao, B. Huang, I.D. RobertsonAbstractA cross-sectional study was undertaken to better understand the husbandry, management and biosecurity practices of pig farms in Guangdong Province (GD), China to identify risk factors for farmer reported swine influenza (SI) on their farms. Questionnaires were administered to 153 owners/managers of piggeries (average of 7 from each of the 21 prefectures in GD). Univariable and multivariable logistic regression analyses were used to identify r...
Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research
In this study, we evaluated the longevity of influenza viruses in aerosols generated in the laboratory. We selected a panel of H1 viruses that exhibit diverse transmission profiles in the ferret model, including four human isolates of swine-origin (referred to as variant) and a seasonal strain. By measuring the ratio of viral RNA to infectious virus maintained in aerosols over time, we show that influenza viruses known to transmit efficiently through the air, display enhanced stability in an aerosol state for prolonged periods compared with those viruses that do not transmit as efficiently. We then assessed whether H1 infl...
Source: Applied and Environmental Microbiology - Category: Microbiology Authors: Tags: Appl Environ Microbiol Source Type: research
Publication date: Available online 12 March 2019Source: Veterinary MicrobiologyAuthor(s): Svenja Mamerow, Robert Scheffter, Susanne Röhrs, Olga Stech, Ulrike Blohm, Theresa Schwaiger, Charlotte Schröder, Reiner Ulrich, Jan Schinköthe, Martin Beer, Thomas C. Mettenleiter, Jürgen StechAbstractInfluenza A viruses (IAV) have caused seasonal epidemics and severe pandemics in humans. Novel pandemic strains as in 2009 may emerge from pigs, serving as perpetual virus reservoir. However, reliably effective vaccination has remained a key issue for humans and swine. Here, we generated a novel double-attenuated inf...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
This study suggests that preventing contact among wild species and swine and using an adaptation area for animals before entry into the herd can be strategies to control the influenza virus in breeding herds.
Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research
Abstract Hemagglutinin (HA) is a glycoprotein found on the surface of influenza A subtype virus H1N1 which play a major role in infection to the human by binding the virus to cells with sialic acid on the membrane of upper respiratory tract or erythrocytes. Based on sequence of HA gene an impedimetric biosensor was developed by immobilizing amino labeled single stranded DNA probe onto cysteine modified gold surface of the screen printed electrode for early and rapid detection of H1N1 (Swine flu) in human. The electrochemical impedance was recorded after hybridization of probe with single stranded cDNA (ss-cDNA) of...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
zhu Ren Porcine circovirus 2 (PCV2) is the etiological agent that causes porcine circovirus diseases and porcine circovirus-associated diseases (PCVD/PCVAD), which are present in every major swine-producing country in the world. PCV2 infections may downregulate the host immune system and enhance the infection and replication of other pathogens. However, the exact mechanisms of PCVD/PCVAD are currently unknown. To date, many studies have reported that several cofactors, such as other swine viruses or bacteria, vaccination failure, and stress or crowding, in combination with PCV2, lead to PCVD/PCVAD. Among these cofactor...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
ichael Veit Shuo Su Influenza C virus (ICV) was first identified in humans and swine, but recently also in cattle, indicating a wider host range and potential threat to both the livestock industry and public health than was originally anticipated. The ICV hemagglutinin-esterase (HE) glycoprotein has multiple functions in the viral replication cycle and is the major determinant of antigenicity. Here, we developed a comparative approach integrating genetics, molecular selection analysis, and structural biology to identify the codon usage and adaptive evolution of ICV. We show that ICV can be classified into six lineage...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
M. I. Nelson et al.
Source: Emerging Infectious Diseases Journal - Category: Infectious Diseases Source Type: research
Abstract Influenza A virus in swine (IAV-S) is an important pathogen in pigs in the United States, in addition to posing a potential risk to humans through zoonotic events. Intervention strategies continue to be explored to better control virus circulation. Improved surveillance efforts has led to significantly increased sequence data available on circulating strains, vastly improving our understanding of the genetic and antigenic diversity of IAV-S. IAV-S in North America is characterized by repeated spillover events of human viruses into pigs followed by genetic and antigenic diversification. An important gap th...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
(CNN) — From climate change to superbugs, the World Health Organization has laid out 10 big threats to our global health in 2019. And unless these threats get addressed, millions of lives will be in jeopardy. Here’s a snapshot of 10 urgent health issues, according to the United Nations’ public health agency: Not vaccinating when you can One of the most controversial recent health topics in the US is now an international concern. “Vaccine hesitancy — the reluctance or refusal to vaccinate despite the availability of vaccines — threatens to reverse progress made in tackling vaccine-prevent...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Local TV Source Type: news
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