Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments.

Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments.
Curr Opin Immunol. 2013 Jan 7;
Authors: Haneklaus M, O'Neill LA, Coll RC
Abstract
The protein NLRP3 has emerged as a central regulator in the inflammatory process, being implicated directly in hereditary cryopyrinopathies, and indirectly in diseases such as gout, Type 2 diabetes and atherosclerosis. NLRP3 is an important regulator of caspase-1, the enzyme that processes the immature form of IL-1β into the active protein. The control of NLRP3 has therefore become a focus of research with evidence for redox regulation, ubiquitination and regulation by miRNA-223, kinases and calcium all emerging as controllers of NLRP3. As our knowledge expands the prospect for precise pharmacological targeting of NLRP3 will improve and could lead to substantial clinical utility.
PMID: 23305783 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - January 7, 2013 Category: Allergy & Immunology Authors: Haneklaus M, O'Neill LA, Coll RC Tags: Curr Opin Immunol Source Type: research