Development, ontogeny, and maintenance of TCR αβ+ CD8αα IEL.

Development, ontogeny, and maintenance of TCRαβ+ CD8αα IEL. Curr Opin Immunol. 2019 May 27;58:83-88 Authors: Ruscher R, Hogquist KA Abstract The intestinal epithelium is the outermost cellular layer that separates the body from the gut lumen. The integrity of this protective mucosal barrier is crucial and maintained by specialized cells-intraepithelial lymphocytes (IEL). Much research has been conducted on these cells and our overall understanding of them is increasing rapidly. In this review we focus on the TCRαβ+ subset of CD8αα IEL. We discuss recent studies that shed light on the development, ontogeny, maintenance, and functional characteristics of CD8αα IEL, and highlight yet unanswered questions for future studies. PMID: 31146182 [PubMed - as supplied by publisher]
Source: Current Opinion in Immunology - Category: Allergy & Immunology Authors: Tags: Curr Opin Immunol Source Type: research

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