The Role of Lipoxin in Regulating Tumor Immune Microenvironments

Publication date: Available online 29 May 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Ting Zhang, Hua Hao, Xiao-Yan ZhouAbstractThe tumor immune microenvironment is the living environment for cancer cells which is essential for supporting cancer cells. Vascular endothelial cells and fibroblasts play a vital role in tumor metastasis and angiogenesis, while macrophages, neutrophils, lymphocytes, and other immune cells play an important role in cancer progression. Lipoxin (LX) is a class of eicosanoids that can regulate components of the innate and adaptive immune system, including the above cells. This review summarizes the roles of LX in the regulation of tumor immune microenvironments in order to throw light on the application of LX in the clinical treatment of tumor immune microenvironments.
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research