The RIG-I pathway is involved in peripheral T cell lymphopenia in patients with dermatomyositis

Peripheral T cell lymphopenia is a clinical phenomenon in some patients with dermatomyositis (DM). Patients with T cell lymphopenia are more susceptible to life-threatening infections. However, the pathogenesi...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research Source Type: research

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AbstractObjectiveNeutrophils are key immune cells participating in host defense through several mechanisms, including the formation of neutrophil extracellular traps (NETs). The role of neutrophils in juvenile dermatomyositis (JDM) is not known.MethodsElectron microscopy was used to identify neutrophils in tissue. NETs were also imaged using fluorescence microscopy, and quantified by an MPO ‐DNA ELISA in plasma from healthy children (n=20), disease controls (n=29), JDM patients (n=66), and JDM patients with history of calcifications (n=20). Clinical data included disease activity scores and complement C4 levels. Levels o...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
This article aims to discuss the role of RHC in diagnosing pulmonary hypertension, its comparison with other modalities, the procedure, and its role in treatment of connective tissue disorders, especially with a special reference to the Indian context. PMID: 31331141 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
ConclusionOur findings indicate that anti ‐TIF1γ IgG2 is a potential new biomarker of cancer that should be helpful in identifying the risk of mortality in anti‐TIF1γ–positive DM patients.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Original Article Source Type: research
Abstract The association between inflammatory myopathies anti-synthetase syndrome and interstitial lung disease has been recognized since the 1950s. Patients generally present with gradual onset of symptoms and slow progression of fibrosis over months to years. Herein, we describe a previously well 51-year-old man who presented with three months of progressive small joint arthritis, cough, dyspnea, and eventually hypoxemic respiratory failure following a viral prodrome. He continued to decompensate despite high dose corticosteroids and mycophenolate mofetil, ultimately requiring extracorporeal membranous oxygenati...
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Respir Med Case Rep Source Type: research
Publication date: Available online 15 June 2019Source: Respiratory Medicine Case ReportsAuthor(s): Andrew R. Deitchman, Or Kalchiem-Dekel, Nevins Todd, Robert M. ReedAbstractThe association between inflammatory myopathies anti-synthetase syndrome and interstitial lung disease has been recognized since the 1950s. Patients generally present with gradual onset of symptoms and slow progression of fibrosis over months to years. Herein, we describe a previously well 51-year-old man who presented with three months of progressive small joint arthritis, cough, dyspnea, and eventually hypoxemic respiratory failure following a viral ...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
This article summarizes the outcome measures most commonly used in paediatric rheumatology. PMID: 31180784 [PubMed - in process]
Source: British Journal of Hospital Medicine - Category: Internal Medicine Authors: Tags: Br J Hosp Med (Lond) Source Type: research
In this study, we retrospectively analyzed data of a group FUO/IUO patients that suspected of PMR, aiming to analyze the imaging features of PMR in FDG PET/CT and evaluate the clinical value of FDG PET/CT in differential diagnosis of PMR. Materials and Methods: From January 2014 to June 2018, among the patients who underwent PET/CT examination because of FUO/IUO, 26 patients were suspected of PMR due to shoulder joint pain and stiffness, increased serum inflammatory factors and age over 50 years old. Clinical and imaging data of these 26 patients were retrospectively analyzed. Final diagnoses were made by board-certified r...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Outcomes/Infectious Disease/Pulmonary Posters Source Type: research
Abstract Common rheumatological disorders encountered in pediatric practice are juvenile idiopathic arthritis, systemic juvenile idiopathic arthritis, Kawasaki disease, Henoch-Schonlein purpura, systemic lupus erythematosus, chronic uveitis and juvenile dermatomyositis. Diagnosis of these disorders requires a critical appraisal of the clinical history, physical examination and relevant investigations. Laboratory tests are helpful for screening purposes as also for confirmation of diagnosis and monitoring of disease activity. These tests should, however, only be ordered after due deliberation and in the context of ...
Source: Indian Pediatrics - Category: Pediatrics Authors: Tags: Indian Pediatr Source Type: research
Abstract Tripterygium wilfordii Hook F. (TWHF), a traditional Chinese medicine, has been widely used to treat autoimmune and inflammatory diseases including rheumatoid arthritis, systemic lupus erythematosus and dermatomyositis in China. Recently, studies have demonstrated that the bioactive components of TWHF have effective therapeutic potential for neurodegenerative diseases including Alzheimer's disease, Parkinson's disease and Multiple Sclerosis. In this paper, we summarize the research progress of triptolide and celastrol (the two major TWHF components) as well as their analogues in the treatment of neurodege...
Source: The American Journal of Chinese Medicine - Category: Complementary Medicine Authors: Tags: Am J Chin Med Source Type: research
Conditions:   SCAD;   Addison Disease;   Ankylosing Spondylitis;   Antiphospholipid Antibody Syndrome;   Celiac Disease;   Crohn Disease;   Dermatomyositis;   Polymyositis;   Guillain-Barre Syndrome;   Hepatitis, Autoimmune;   Graves Disease;   Hashimoto Thyroiditis;   Multiple Sclerosi s;   Myasthenia Gravis;   Pernicious Anemia;   Polymyalgia Rheumatica;   Primary Biliary Cirrhosis;   Psoriasis;   Rheumatoid Arthritis;   Systemic Scle...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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