A truncated Snail1 transcription factor alters expression of essential EMT markers and suppresses tumor cell migration in a human lung cancer cell line.

CONCLUSIONS: Transfection of A549 cells with CSnail1 alters expression of essential EMT markers and consequently suppresses tumor cell migration. These findings confirm capability of CSnail1 in EMT blocking and in parallel to current patents could be applied as a novel strategy in prevention of metastasis. PMID: 31131753 [PubMed - as supplied by publisher]
Source: Recent Patents on Anti-Cancer Drug Discovery - Category: Cancer & Oncology Tags: Recent Pat Anticancer Drug Discov Source Type: research