Poor Performance Flagging Is Associated With Fewer Transplantations at Centers Flagged Multiple Times
ConclusionsThis analysis defines center-level trends in lung transplantation after CMS flagging. Contrary to our primary hypothesis, flagging did not result in temporal center-level changes. However, programs on prolonged probation demonstrated reduced activity, which likely indicates a shift to higher performing centers.
Publication date: Available online 15 June 2019Source: Respiratory Medicine Case ReportsAuthor(s): Andrew R. Deitchman, Or Kalchiem-Dekel, Nevins Todd, Robert M. ReedAbstractThe association between inflammatory myopathies anti-synthetase syndrome and interstitial lung disease has been recognized since the 1950s. Patients generally present with gradual onset of symptoms and slow progression of fibrosis over months to years. Herein, we describe a previously well 51-year-old man who presented with three months of progressive small joint arthritis, cough, dyspnea, and eventually hypoxemic respiratory failure following a viral ...
We describe the use of transnasal humidified rapid-insufflation ventilatory exchange for deep sedation during dental extractions in a patient with severe cystic fibrosis as a precondition for lung transplantation. Patient wanted to have the procedure under general anesthesia with intubation due to extreme anxiety. However, we advocated deep IV sedation with transnasal humidified rapid-insufflation ventilatory exchange. Oxygenation was maintained without airway obstruction and pulmonary complications during the entire procedure of 110 minutes.
Objective To evaluate the diagnostic value of function volume/morphological volume ratio calculated from ventilation/perfusion single-photon emission computed tomography/computed tomography in distinguishing the lungs with bronchiolitis obliterans syndrome (BOS) from the lungs without this syndrome after lung transplantation and to assess its relationship with spirometry parameters. Materials and methods We retrospectively identified 84 consecutive lung transplant recipients and 13 donors who underwent ventilation/perfusion single-photon emission computed tomography/computed tomography. Differences in the function vol...
CONCLUSIONS: FOXF1 acts through STAT3 to stimulate neonatal lung angiogenesis. Nanoparticle delivery of STAT3 is a promising strategy to treat ACDMPV associated with decreased STAT3 signaling. PMID: 31199666 [PubMed - as supplied by publisher]
CONCLUSIONS: Adding CF-specific variables improved discrimination among waitlisted CF candidates, and benefitted COPD candidates. PMID: 31199166 [PubMed - as supplied by publisher]
Conclusions: ECLS is an essential tool in the armamentarium of any lung transplant program treating iPAH with a potential of bridge patients to transplantation and to overcome graft dysfunction after LTx. Despite utilization of ECLS in the management of iPAH, the outcomes in terms of primary graft failure and survival remain poor compared to patients with other diagnoses. PMID: 31183172 [PubMed]
Conclusions: Our study suggests that MCs are recruited into NSCLC microenvironment and improve the EMT and migration of cancer cells, thereby accelerating the growth of NSCLC.
Annually, the number of people awaiting transplants far exceeds the number of donors. For certain patients requiring lung transplantation, size matters. In addition to matching blood and tissue type, organ size plays a significant role. "For certain lung transplant patients, for example, the size of their chest cavity may be mismatched due to the nature of [...]
Consistent achievement of life-supporting cardiac xenograft function in a preclinical model is the benchmark established by an International Society for Heart and Lung Transplantation expert advisory panel in 2000 as a precondition for clinical translation.1 This long-elusive goal appears to be close at hand based on a recent report by L ängin and colleagues,1 published late last year in Nature.2 The Munich-based team reported that 4 of 5 consecutive baboon recipients of orthotopically implanted genetically modified pig hearts survived beyond 90 days.
This study aimed to investigate whether FCGR2A and FCGR3A polymorphisms can also be associated with the clinical outcome of lung transplant recipients (LTRs). The SNPs of FCGR2A ([131R/H], rs1801274) and FCGR3A ([158V/F], rs396991) were identified in 158 LTx recipients (LTR) and 184 Controls (CTL). The corresponding distribution of genotypic and allelic combinations was analyzed for potential links with the development of circulating donor-specific anti-HLA alloantibodies (DSA) detected at months 1 and 3 after lung transplant (LTx), the occurrence of acute rejection (AR) and chronic lung allograft dysfunction (CLAD), and...