Shape Follows Function: Gastrointestinal Signals for Enterococcal Colonization.
Shape Follows Function: Gastrointestinal Signals for Enterococcal Colonization.
Trends Mol Med. 2019 May 17;:
Authors: Nguyen AH, Miller WR, Arias CA
Abstract
Vancomycin-resistant Enterococcus faecium (VRE) is a major cause of nosocomial infections. A new study by McKenney et al. (Cell Host Microbe 2019;25:695-705.e5) reports that VRE undergo a morphotype switch in response to lithocholic acid (LCA) to facilitate gastrointestinal (GI) tract colonization. This metabolic cue is a potential target to decrease VRE colonization and subsequent transmission of antibiotic resistance.
PMID: 31109795 [PubMed - as supplied by publisher]
Source: Trends in Molecular Medicine - Category: Molecular Biology Authors: Nguyen AH, Miller WR, Arias CA Tags: Trends Mol Med Source Type: research