Anti-HCV protease potential of endophytic fungi and cytotoxic activity

Publication date: Available online 21 May 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Lamia Abou El-Kassem, Usama W. Hawas, Sahar El-Souda, Eman F. Ahmed, Wail El-Khateeb, Walid FayadAbstractForty-eight endophytic fungal strains were isolated and purified from ten Egyptian medicinal plants and their culture broth extracts were explored for HCV protease inhibitory activity and cytotoxicity. The ethyl acetate extracts of Alternaria alternata PGL-3, Cochlibolus lunatus PML-17, Nigrospora sphaerica EPS-38, followed by Emerecilla nidulans RPL-21 showed the most potent inhibition of HCV NS3/4A protease with IC50 17.0, 20.5, 33.6, and 54.6 μg/ml, respectively, with low cytotoxicity except for the later. The extracts of Emericella nidulans RSL-24, Fusarium oxysporum SML-41, Emericella nidulans RPL-21, and Penicillium sp. RSL-43 exhibited strong cytotoxic activity against human breast cancer cell lines (MCF-7) with IC50 10.8, 11.0, 12.5, and 13.7 μg/ml, respectively. Emericella nidulans RSS-22, Emericella nidulans RSL-24, and Fusarium oxysporum SML-41 displayed a potent cytotoxic effect on human liver cancer cell lines (HEP-G2) with IC5014.8, 20.3 and 24.0 μg/ml, respectively. Alternariol and alternariol -9-methyl ether were isolated from the ethyl acetate extract of Alternaria alternata PGL-3 whereas, emericellin, shamixanthone, arugosin C were isolated from the ethyl acetate extract of Emericella nidulans RPL-21. The results suggest Alternaria al...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research

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Conclusions Women with newly diagnosed breast cancer are likely to experience higher rates of work-related disability compared with health counterparts. Health care providers should provide intervention to parallel the shift in symptoms that lead to higher work-related disability and job cessation.
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Brief Reports Source Type: research
This study provides insight into potential risk factors for functional decline and lack of resilience in older women receiving adjuvant chemotherapy for breast cancer.Journal of the American Geriatrics Society
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Internal Medicine Journal Article Source Type: news
ConclusionWe report the first randomized trial evaluating the impact of in-depth RT plan review on PRO during breast radiation. Both baseline and post-intervention scores were high for all domains. Detailed patient assessment, understanding of communication types and information processing may be necessary to determine subtle PRO differences. Further investigations of PRO could potentially direct and optimize physician and patient communication during RT.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Conclusion4D heart blocks accounting for intrinsic respiratory motion and cardiac motion are greater in size than FB heart blocks. These larger blocks result from the larger contour created from the MIP image and block more dose to the heart. This technique for improving custom heart blocks can be easily implemented with 4DCT machine capabilities currently available in clinical practice.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Date: Thursday, 06 20, 2019; Speaker: Etta Pisano, MD, Professor in Residence of Radiology and PI for TMIST, Harvard Medical School; Worta McCaskill-Stevens, MD, MS, Chief, Community Oncology and Prevention Trails Research Group, Division of Cancer Prevention, NCI; Carolyn D. Runowicz, MD, Executive Associate Dean for Academic Affairs, Professor of OB/GYN, Herbert Wertheim College of Medicine, FIU; Building: Building 45 (Natcher Building); Conference Room A/B; CME Credit; Videocast Event
Source: NIH Calendar of Events - Category: American Health Source Type: events
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Publication date: 18 June 2019Source: Cell Reports, Volume 27, Issue 12Author(s): Sunghee Park, Rachid Safi, Xiaojing Liu, Robert Baldi, Wen Liu, Juan Liu, Jason W. Locasale, Ching-yi Chang, Donald P. McDonnellSummaryMost cancer cells exhibit metabolic flexibility, enabling them to withstand fluctuations in intratumoral concentrations of glucose (and other nutrients) and changes in oxygen availability. While these adaptive responses make it difficult to achieve clinically useful anti-tumor responses when targeting a single metabolic pathway, they can also serve as targetable metabolic vulnerabilities that can be therapeuti...
Source: Cell Reports - Category: Cytology Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Publication date: Available online 19 June 2019Source: Biosensors and BioelectronicsAuthor(s): Sattar Akbari Nakhjavani, Hadi Afsharan, Balal Khalilzadeh, Mohammad Hossein Ghahremani, Sandro Carrara, Yadollah OmidiAbstractCarcinoembryonic antigen (CEA) is an important oncomarker for the detection of breast cancer. For ultra-sensitive sensing of CEA with great specificity and accuracy, an innovative and reliable electrochemical immunosensor was developed using various nano-hybrids. A glassy carbon electrode (GC) was modified with thiolated graphene oxide (T-GO) to elevate the active surface area of the electrode. The strept...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Publication date: Available online 19 June 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Diana C. Márquez-Garbán, Gang Deng, Begonya Comin-Anduix, Alejandro J. Garcia, Yanpeng Xing, Hsiao-Wang Chen, Gardenia Cheung-Lau, Nalo Hamilton, Michael E. Jung, Richard J. PietrasAbstractBreast cancers (BC) with expression of estrogen receptor-alpha (ERα) occur in more than 70% of newly-diagnosed patients in the U.S. Endocrine therapy with antiestrogens or aromatase inhibitors is an important intervention for BCs that express ERα, and it remains one of the most effective tar...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
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