Posttranscription Initiation Control of Gene Expression Mediated by Bacterial RNA-Binding Proteins.

Posttranscription Initiation Control of Gene Expression Mediated by Bacterial RNA-Binding Proteins. Annu Rev Microbiol. 2019 May 17;: Authors: Babitzke P, Lai YJ, Renda A, Romeo T Abstract RNA-binding proteins play vital roles in regulating gene expression and cellular physiology in all organisms. Bacterial RNA-binding proteins can regulate transcription termination via attenuation or antitermination mechanisms, while others can repress or activate translation initiation by affecting ribosome binding. The RNA targets for these proteins include short repeated sequences, longer single-stranded sequences, RNA secondary or tertiary structure, and a combination of these features. The activity of these proteins can be influenced by binding of metabolites, small RNAs, or other proteins, as well as by phosphorylation events. Some of these proteins regulate specific genes, while others function as global regulators. As the regulatory mechanisms, components, targets, and signaling circuitry surrounding RNA-binding proteins have become better understood, in part through rapid advances provided by systems approaches, a sense of the true nature of biological complexity is becoming apparent, which we attempt to capture for the reader of this review. Expected final online publication date for the Annual Review of Microbiology Volume 73 is September 9, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates. ...
Source: Annual Review of Microbiology - Category: Microbiology Authors: Tags: Annu Rev Microbiol Source Type: research