Systematic review and meta-analysis of clinical use of HIV integrase inhibitors

Source: PLoS One Area: News Integrase inhibitors have swiftly been adopted as part of current antiretroviral regimens. This systematic review and meta-analysis was carried of current evidence regarding the use of these agents in various clinical settings.   A search was conducted of the literature from April 2006 until November 2012, for RCTs and non-RCTs, and cohort studies. A total of 48 unique studies (including 15 abstract-only reports) were included on the use of integrase inhibitors in antiretroviral therapy-naive patients and treatment-experienced patients with either virological failure or switching to integrase inhibitors while virologically suppressed. These studies included over 9400 HIV-infected patients and 38 (79%) of them described use of raltegravir. Elvitegravir and dolutegravir were respectively investigated in 5 (10%) studies each. The average study population size was 202 and the average study duration was 48 weeks.   A meta-analysis was performed on selected studies ...
Source: NeLM - News - Category: Drugs & Pharmacology Source Type: news