Exosomal long non-coding RNAs: biological properties and therapeutic potential in cancer treatment.

Exosomal long non-coding RNAs: biological properties and therapeutic potential in cancer treatment.
J Zhejiang Univ Sci B. 2019 Jun;20(6):488-495
Authors: Luo J, Xiong Y, Fu PF, Li EC, Qu L, Fan X, Cai ZJ, Lin AF
Abstract
Exosomes and long non-coding RNAs (lncRNAs) are emerging as important elements contributing to a more comprehensive understanding of cancer development and progression. The discovery of lncRNAs in exosomes further indicates their bona fide biological functional roles in cancer development and drug resistance. In this review, we describe the biogenesis of exosomes and summarize the function of exosomal lncRNAs in the field of cancer research. These findings strikingly advance current knowledge of exosomal lncRNAs and suggest that they may be promising diagnostic biomarkers and therapeutic targets for cancer.
PMID: 31090274 [PubMed - in process]

Source: J Zhejiang Univ Sci ... - May 17, 2019 Category: Science Authors: Luo J, Xiong Y, Fu PF, Li EC, Qu L, Fan X, Cai ZJ, Lin AF Tags: J Zhejiang Univ Sci B Source Type: research