Sentinel lymph node biopsy following previous axillary surgery in recurrent breast cancer

Publication date: Available online 16 May 2019Source: European Journal of Surgical OncologyAuthor(s): Á. Sávolt, G. Cserni, Gy Lázár, R. Maráz, P. Kelemen, E. Kovács, B. Győrffy, N. Udvarhelyi, A. Vörös, K. Ormandi, Z. MátraiAbstractIntroductionIpsilateral breast recurrence or second primary breast cancer can develop in patients who have undergone breast conserving surgery (BCS) and axillary surgery. The purpose of this study was to examine the feasibility of a reoperative sentinel lymph node biopsy (SLNB) as a repeated axillary staging procedure.Patients and methodsFrom August 2014 through January 2017 patients with locally recurrent breast cancer or with BRCA mutation requiring risk reduction mastectomy as a second surgical procedure, underwent repeat SLNB in three Hungarian Breast Units with a radiocolloid (and blue dye) technique.ResultsHundred and sixty repeat SLNBs were analysed, 80 after previous SLNB and 80 after previous total or partial axillary lymph node dissection (ALND). SLN identification was successful in 106 patients (66%); 77/80 (77.5%) and 44/80 (55%) in the SLNB and ALND groups, respectively. (p 
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research

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Publication date: Available online 17 October 2019Source: European Journal of RadiologyAuthor(s): Said Pertuz, Antti Sassi, Kirsi Holli-Helenius, Joni Kamarainen, Irina Rinta-Kiikka, Anna-Leena Laaperi, Otso ArponenAbstractPurposeTo assess the association between breast cancer risk and mammographic parenchymal measures obtained using a fully-automated, publicly available software, OpenBreast.MethodsThis retrospective case-control study involved screening mammograms of asymptomatic women diagnosed with breast cancer between 2016 and 2017. The 114 cases were matched with corresponding healthy controls by birth and screening ...
Source: European Journal of Radiology - Category: Radiology Source Type: research
Conclusion: TA flap has a simple design that minimizes concerns involving the donor site. Moreover, it does not require complicated procedures and allows for re-elevation whenever necessary. Finally, it guarantees faster wound recovery than skin graft with fewer complications. PMID: 31620390 [PubMed]
Source: Annals of Surgical Treatment and Research - Category: Surgery Tags: Ann Surg Treat Res Source Type: research
Publication date: December 2019Source: Biomedicine &Pharmacotherapy, Volume 120Author(s): Neng Wang, Bowen Yang, Gulizeba Muhetaer, Shengqi Wang, Yifeng Zheng, Jiahong Lu, Min Li, Fengxue Zhang, Honglin Situ, Yi Lin, Zhiyu WangAbstractXIAOPI formula is a national approved drug prescribed to patients with high breast cancer risk. Previously we demonstrated that XIAOPI formula could inhibit breast cancer metastasis via suppressing CXCL1 expression, and postulated that “autophagy in cancer” might be one of its most core anti-cancer mechanisms. However, whether XIAOPI formula could be simultaneously applied wit...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
In conclusion, our data showed differences in the distribution of the mutation spectrum of BRCA1 and BRCA2 in Turkey.
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
ConclusionWe suggest that CD4+CD25−FoxP3+ cells in patients with BC are exhausted cells with an intermediate phenotype between effector and regulatory cells.
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Introduction The current study aimed to investigate the diagnostic performance of metabolic parameters of pre-treatment F-18 fluorodeoxyglucose PET/computed tomography for predicting axillary lymph node metastases, distant metastases, and overall survival rates in breast cancer patients. Materials and methods One hundred thirteen breast cancer patients who underwent pre-treatment F18 [FDG] PET-computed tomography with biopsy-proven axillary lymph node status were included in the current study. In pre-treatment F18 [FDG] PET-computed tomography for primary tumour area maximum standard uptake value, metabolic tumour vol...
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
Objective The aim of this study was to compare the diagnostic precision of bone scintigraphy with BONENAVI version 1 and BONENAVI version 2 in bone metastasis of primary breast cancer. Methods The subjects were 56 consecutive patients (all women, mean age 59 ± 12.7 years) who underwent bone scintigraphy with 99mTc-MDP and were diagnosed with bone metastasis of primary breast cancer from January 2012 to November 2014. Bone scintigraphy was performed with BONENAVI version 1 and BONENAVI version 2 to calculate artificial neural network (ANN), bone scan index (BSI), and hot-spot values, with ANN ≥ 0.5 considered...
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
Conclusion Lung shunt fraction appears low among patients with non-hepatocellular carcinoma liver malignancies. Further analysis examining the necessity of pre-Y90 technetium-99 m macro aggregated albumin lung shunt fraction studies in patients with non-hepatocellular carcinoma malignancies is warranted, since a consolidated yttrium-90 radioembolization without prior lung shunt fraction evaluation could reduce resource consumption, improve workflows, and patient access.
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
Condition:   Breast Cancer Intervention:   Sponsor:   Ottawa Hospital Research Institute Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Breast Cancer;   Drug Effect Intervention:   Sponsors:   Peking University People's Hospital;   Peking University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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