Effects of accelerated corneal crosslinking on the topographic parameters of patients with progressive keratoconus

ABSTRACT Glaucoma is the leading cause of irreversible blindness worldwide and can affect a broad array of daily activities, including driving. Recently, studies investigating the relationship between driving performance and glaucoma have received a great deal of interest. Assessment of driving behavior is not straightforward because driving is a complex skill involving significant multi-tasking ability. In this review, we summarize recent work from clinical studies investigating how glaucoma can affect driving performance. Patients with glaucoma are more likely to be involved in motor vehicle collisions when compared to healthy subjects. Here we describe how conventional functional tests performed in glaucoma patients, such as visual field measurements via standard automatic perimetry, are associated with driving performance. However, the risk of motor vehicle collisions is not entirely attributable to visual field impairment in glaucoma, suggesting that other factors also account for both driving safety and performance. Finally, we show different studies suggesting that parameters from driving simulators can be helpful because they can identify the impact of visual loss on complex situations.RESUMO O glaucoma é a principal causa de cegueira irreversível em todo o mundo e pode afetar uma ampla gama de atividades diárias, incluindo a direção veicular. Recentemente, estudos que investigam a relação entre o desempenho na condu&cc...
Source: Arquivos Brasileiros de Oftalmologia - Category: Opthalmology Source Type: research

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Publication date: Available online 14 October 2019Source: The Lancet Diabetes &EndocrinologyAuthor(s): Dinesh Selvarajah, Debasish Kar, Kamlesh Khunti, Melanie J Davies, Adrian R Scott, Jeremy Walker, Solomon TesfayeSummaryDiabetic peripheral neuropathy (DPN) is a common complication of both type 1 and 2 diabetes. It is a leading cause of lower-limb amputation and disabling neuropathic pain. Amputations in patients with diabetes have a devastating effect on quality of life and are associated with an alarmingly low life expectancy (on average only 2 years from the amputation). Amputation also places a substantial financ...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Conditions:   Retinitis Pigmentosa;   Eye Diseases Intervention:   Sponsors:   Jaeb Center for Health Research;   Foundation Fighting Blindness Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
TUESDAY, Oct. 15, 2019 -- Severe sleep apnea is a risk factor for diabetic eye disease that can lead to vision loss and blindness, researchers report. Poor control of diabetes can result in damage to tiny blood vessels at the back of the eye, a...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Eye, Published online: 15 October 2019; doi:10.1038/s41433-019-0625-6Selective laser trabeculoplasty as the primary treatment for open angle glaucoma: time for change?
Source: Eye - Category: Opthalmology Authors: Source Type: research
Untreated distance vision impairment in low- and middle-income regions is about four times higher than in high-income regions, and $14.3 billion (U.S. dollars) is needed to treat the 1 billion people with vision impairment or blindness due to cataracts, and short- and far-sightedness, the report said.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Kelsey Moody of Ichor Therapeutics presented on the LysoClear development program at the Ending Age-Related Diseases conference organized by the Life Extension Advocacy Foundation earlier this year. LysoClear is an example of the commercial development of a rejuvenation therapy, taken all the way from the starting point of the discovery of microbial enzymes capable of breaking down certain forms of harmful age-related molecular waste that contribute to aging and age-related diseases. The actual research is largely done, and the task now is to focus on manufacture, regulatory approval, and entry into the clinic. Take...
Source: Fight Aging! - Category: Research Authors: Tags: Healthy Life Extension Community Source Type: blogs
Gene Therapy, Published online: 14 October 2019; doi:10.1038/s41434-019-0105-4Transduction optimization of AAV vectors for human gene therapy of glaucoma and their reversed cell entry characteristics
Source: Gene Therapy - Category: Genetics & Stem Cells Authors: Source Type: research
AbstractDiabetic retinopathy (DR) is a frequent complication of diabetes mellitus, and a common cause of vision impairment and blindness in these patients, yet many aspects of its pathogenesis remain unresolved. Furthermore, current treatments are not effective in all patients, are only indicated in advanced disease, and are associated with significant adverse effects. This review describes the microvascular features of DR, and how pericyte depletion and low-grade chronic inflammation contribute to the pathogenesis of this common ophthalmic disorder. Existing, novel and investigational pharmacological strategies aimed at m...
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research
Fuchs uveitis syndrome (FUS) is a chronic, typically unilateral, ocular condition characterized by an asymptomatic mild inflammatory syndrome that can result in cataract and secondary glaucoma. Diagnosis is largely clinical because the etiology remains obscure. FUS is most likely the result of different insults or pathogenic mechanisms, including infections, autoimmune diseases, hereditary and sympathetic dysfunction. According to the infectious theory, the infection of herpes simplex virus, ocular toxoplasmosis, cytomegalovirus, rubella virus, and other viruses have been implicated in the pathogenesis of the disease.
Source: Survey of Ophthalmology - Category: Opthalmology Authors: Tags: Major review Source Type: research
e E Gilbert The Sustainable Development Goals aim to leave no one behind. We explored the hypothesis that women without a living spouse—including those who are widowed, divorced, separated, and never married—are a vulnerable group being left behind by cataract services. Using national cross-sectional blindness surveys from Nigeria (2005–2007; n = 13,591) and Sri Lanka (2012–2014; n = 5779) we categorized women and men by marital status (married/not-married) and place of residence (urban/rural) concurrently. For each of the eight subgroups we calculated cataract blindness, catarac...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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