Tips to Stay Safe in the Sun: From Sunscreen to Sunglasses

The U.S. Food and Drug Administration is continuing to evaluate sunscreen products to help protect consumers from sunburn. Because certain sunscreens can help prevent skin cancer caused by the sun when used as directed with other sun protection measures, it's important to know how to use them properly. Also learn about other ways to protect yourself from sun damage.
Source: FDA Consumer Health Information Updates - Category: Consumer Health News Authors: Source Type: news

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Abstract Recent reports describe how genome-wide transcriptional analysis of cancer tissues can be exploited to identify molecular signatures of immune infiltration in cancer. We hypothesize that immune infiltration in cancer may also be defined by changes in certain epigenetic signatures. In this context, a primary objective is to identify site-specific CpG markers whose levels of methylation may be highly indicative of known transcriptional markers of immune infiltration such as GZMA, PRF1, T cell receptor genes, PDCD1, and CTLA4. This has been accomplished by integrating genome-wide transcriptional expression a...
Source: Advances in Cancer Research - Category: Cancer & Oncology Authors: Tags: Adv Cancer Res Source Type: research
Conditions:   Melanoma;   Hodgkin Lymphoma;   Non Small Cell Lung Cancer Intervention:   Sponsor:   University of Cologne Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
(Oregon State University) Researchers have found a possible counterpunch to the drug resistance of melanoma, the most dangerous form of skin cancer.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Squamous cell carcinoma in the head and neck region is one of the most widespread cancers with high morbidity. Classic treatment comprises the complete removal of the lymphatics together with the cancerous tis...
Source: EJNMMI Physics - Category: Radiology Authors: Tags: Original research Source Type: research
AbstractExtramammary Paget's disease (EMPD) is a rare cutaneous adenocarcinoma that clinicopathologically resembles breast cancer. The prognosis of metastatic EMPD is poor. Although several chemotherapies have been tried, the effects are temporary; better drugs and combinations are required.In the present study, we retrospectively analyze the efficacy and safety of combination of cisplatin, epirubicin, and paclitaxel in five metastatic EMPD cases. The efficacy was better than that for previously reported regimens: 80% partial responses, including two patients who were refractory to taxane‐ and/or platinum‐based regimen...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Melanoma and Cutaneous Malignancies Brief Communications Source Type: research
We present an illustrative case of a 60‐year‐old man with metastatic melanoma who presented with AKI during treatment with nivolumab and review the literature to address frequently asked questions concerning the diagnosis and management of renal irAEs in patients with advanced cancer. Importantly, most patients will recover completely, and some may tolerate a rechallenge of ICI therapy, with prompt and effective treatment.Key Points. Renal immune‐related adverse events (irAEs) are less frequently reported than other irAEs; however, it is possible that available data underestimate their true incidence because of misse...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: New Drug Development and Clinical Pharmacology Immune ‐ Related Adverse Events Source Type: research
Conclusion.IC with Genexol‐PM and cisplatin demonstrated modest tumor response with well‐tolerated toxicity profiles for patients with LA‐HNSCC.
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Head and Neck Cancers, Chinese Edition, Clinical Trial Results Source Type: research
Gangemi Among Uveal Melanoma (UM) driver mutations, those involving GNAQ or GNA11 genes are the most frequent, while a minor fraction of tumors bears mutations in the PLCB4 or CYSLTR2 genes. Direct inhibition of constitutively active oncoproteins deriving from these mutations is still in its infancy in UM, whereas BRAFV600E-targeted therapy has obtained relevant results in cutaneous melanoma. However, UM driver mutations converge on common downstream signaling pathways such as PKC/MAPK, PI3K/AKT, and YAP/TAZ, which are presently considered as actionable targets. In addition, BAP1 loss, which characterizes UM metastati...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Conclusion: Our results establish the functional role of RNF128 in driving the invasion and metastasis of ESCC through the EGFR/MAPK/MMP-2 pathway, implicating its potential as a candidate therapeutic target and prognostic biomarker for ESCC.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
This study reveals diverse T-cell clones in the blood of melanoma patients prior to immunotherapy, which may reflect the extent to which T cells are able to react against melanoma and potentially control melanoma progression. Therefore the T-cell clonality in the circulation may have predictive value for antitumor responses from checkpoint inhibition.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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