Alzheimer's could be spotted up to 34 YEARS before symptoms begin

A study by Johns Hopkins University found patients who are at risk of the disease have elevated levels of the protein tau in their spinal fluid up to 34.4 years before they show signs of memory loss.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Condition:   Falls (Accidents) in Old Age Interventions:   Behavioral: FallsTalk-C;   Behavioral: FallsTalk Sponsors:   Brookside Research & Development Company;   National Institute on Aging (NIA);   Alzheimer's Association- Washington State Chapter Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
It’s funny how people only start thinking about death when either a loved one has passed away, or they’re facing their own imminent mortality. But the time to talk and think about death is not at the end — but throughout your life. Because unbeknownst to you, there is an entire profession aligned against you having a good death. And that is (nearly) the entire profession of doctors. I was listening to “Fresh Air” on NPR yesterday with Terry Gross speaking to bioethicist Tia Powell about having a good death with dementia, among other topics. It made me think of my own dad’s recent death...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Death & Dying Ethics & Morality Family General Grief and Loss Policy and Advocacy Professional Source Type: blogs
In this study, we have examined the molecular mechanism of the toxicity of acetylated K274-tau. We incorporated an acetylation mimicking mutation at K274 (K->Q) residue of tau. The mutation (K274Q) strongly reduced the ability of tau to bind to tubulin and also to polymerize tubulin while K274R mutation did not reduce the ability of tau either to bind or polymerize tubulin. In addition, K274Q-tau displayed a higher aggregation propensity than wild-type tau as evident from thioflavin S fluorescence, tryptophan fluorescence, and electron microscopic images. Furthermore, dynamic light scattering, atomic force microscopy, a...
Source: Biochemical Journal - Category: Biochemistry Authors: Tags: Research Articles Source Type: research
Alzheimer ’s disease (AD) is a neurodegenerative disorder characterized by progressive memory loss due to aberrant accumulation of misfolded proteins inside and outside neurons and glial cells leading to a loss of cellular protein homeostasis. Today, no therapy is available to block or slow down AD progress ion and the mechanisms of the disease are not fully understood. Autophagy is an intracellular degradation pathway crucial to maintaining cellular homeostasis by clearing damaged organelles, pathogens, and unwanted protein aggregates.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Review Source Type: research
As my patients aged along with me, I noticed both the expected increased numbers of people with some form of dementia and even more patients who were worried about this topic. Unless you have been away on a ten-year safari, you are very aware that dementia is a growing problem. Some 5.8 million Americans are […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Neurology Source Type: blogs
Conclusion: Our findings suggest that GA may be a therapeutic agent for the treatment of neuroinflammation and cognitive impairment. PMID: 31073286 [PubMed]
Source: Food and Nutrition Research - Category: Nutrition Authors: Tags: Food Nutr Res Source Type: research
(Natural News) Many people assume that dementia is a “normal” part of the aging process — but the truth is that memory loss and cognitive decline are not rites of passage in your golden years. Recent survey data from the Dementia Attitudes Monitor shows that over 20 percent of people in the United Kingdom believe...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
This study evaluates the effect of hydroalcoholic extract of E. amoenum flowers on scopolamine-induced memory impairment in rats. MATERIALS AND METHODS: Fifty male Wistar rats were randomly divided into five groups. Control group received normal saline, model group received scopolamine (0.7 mg/kg, IP, daily for 21 days), and test groups received E. amoenum extract (50, 75, and 100 mg/kg, IP, daily for 21 days) 30 min before each scopolamine injection. The elevated plus maze (EPM), shuttle box, novel object and rotarod tests were performed after treatment. Brain levels of malondialdehyde (MDA) and t...
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
The research from thisAlzheimer's memory test, Self-Administered Geocognitive Examination (SAGE), shows that four out of five people (80 percent) with memory issues will be detected by this test.Ninety-five percent (95) of people who are normal thinking (memory) will have normal SAGE scores.Please note.If you find the test results suspicious,you should contact your doctor immediately, and ask for aneurological or geriatric consult.These specialist can determine, through a series of tests, whether or not you are suffering from or headed for Alzheimer's disease.What's the Difference Between Alzheimer ’s and DementiaSAG...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer test alzheimers symptom caring for dementia caring for dementia patients dementia test memory loss memory test sage test test your memory Source Type: blogs
DISCUSSION: TDP-43 is associated with greater brain atrophy in PART. PMID: 31056344 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
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