Hit and run versus long-term activation of PARP-1 by its different domains fine-tunes nuclear processes [Genetics]

Poly(ADP-ribose) polymerase 1 (PARP-1) is a multidomain multifunctional nuclear enzyme involved in the regulation of the chromatin structure and transcription. PARP-1 consists of three functional domains: the N-terminal DNA-binding domain (DBD) containing three zinc fingers, the automodification domain (A), and the C-terminal domain, which includes the protein interacting WGR domain...

Source: Proceedings of the National Academy of Sciences - May 13, 2019 Category: Science Authors: Colin Thomas, Yingbiao Ji, Chao Wu, Haily Datz, Cody Boyle, Brett MacLeod, Shri Patel, Michelle Ampofo, Michelle Currie, Jonathan Harbin, Kate Pechenkina, Niraj Lodhi, Sarah J. Johnson, Alexei V. Tulin Tags: Biological Sciences Source Type: research