Adverse Childhood Experiences Linked to Worse Lupus Outcomes

More adverse childhood experiences associated with depression, poor overall health for those with SLE
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Family Medicine, Gynecology, Internal Medicine, Nephrology, Pathology, Pediatrics, Psychiatry, Rheumatology, Journal, Source Type: news

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Abstract Systemic lupus erythematosus (SLE) is a chronic, devastating autoimmune disorder associated with severe organ damage. Recently, the role of Signal Transducer and Activator of Transcription 3 (STAT3) in murine lupus has been described, suggesting the involvement of STAT3 signaling in the development of SLE. Cryptotanshinone (CTS) is an effective inhibitor of STAT3; however its potential as a SLE treatment remains to be explored. To determine the function of CTS in SLE, we treated MRL/lpr female mice with CTS. Firstly, we found CTS treatment reversed the elevated STAT3 signaling of spleens in lupus-prone MR...
Source: International Immunopharmacology - Category: Allergy & Immunology Authors: Tags: Int Immunopharmacol Source Type: research
CONCLUSION: These findings suggest that the PALS intervention was effective in improving patient-level factors and was cost-effective. Future research will need to validate these findings in a larger sample. PMID: 31166867 [PubMed - as supplied by publisher]
Source: Lupus - Category: Rheumatology Authors: Tags: Lupus Source Type: research
CONCLUSION: Over one-third of patients with SLE in our cohort were found to have MCI. Risk factors included male gender, lower educational level, higher pain score and presence of anticardiolipin IgM. Physicians are encouraged to perform routine screening to detect cognitive dysfunction in patients with SLE in their clinical practice as part of a more comprehensive management. PMID: 31159651 [PubMed - as supplied by publisher]
Source: Lupus - Category: Rheumatology Authors: Tags: Lupus Source Type: research
CONCLUSIONS: Identification of clusters of patients according to HRQoL levels could be useful to improve SLE management, aiming at personalised medicine. PMID: 31140392 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Abstract OBJECTIVES: Hydroxychloroquine (HCQ) is a key therapy in systemic lupus erythematosus (SLE). Medication non-adherence is reported in up to 80% of lupus patients and results in increased morbidity, mortality, and health care utilization. HCQ levels are a sensitive and reliable method to assess medication adherence. Our study evaluated the role of HCQ level measurement in routine clinical care and its association with disease activity in a predominantly Hispanic population. METHODS: SLE patients from the Columbia University Lupus cohort treated with HCQ for ≥ 6 months and reporting med...
Source: Lupus - Category: Rheumatology Authors: Tags: Lupus Source Type: research
We examined if childhood abuse was associated with heightened risk of incident systemic lupus erythematosus (SLE). METHODS: Data were from the Nurses' Health Study II, a cohort of U.S. female nurses enrolled in 1989, followed with biennial questionnaires. We measured childhood physical and emotional abuse with the Physical and Emotional Abuse Subscale of the Childhood Trauma Questionnaire and sexual abuse with the Sexual Maltreatment Scale of the Parent-Child Conflict Tactics Scale, both administered in 2001. We identified incident SLE (>4 American College of Rheumatology 1997 classification criteria) through 2015. ...
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
The greater the number of bad childhood experiences, the worse a patient's self-reported lupus activity, depression and overall health, a new study has found.
Source: WebMD Health - Category: Consumer Health News Source Type: news
(Wiley) Adverse childhood experiences (ACEs) encompass traumas such as abuse, neglect, and household challenges. In an Arthritis Care&Research study of adults with lupus, higher ACE levels, as well as the presence of ACEs from each of these three domains, were associated with worse patient-reported accounts of disease activity, organ damage, depression, physical function, and overall health status.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(University of California - San Francisco) Adults with lupus who report having had adverse childhood experiences (ACEs), such as abuse, neglect and household challenges, report higher disease activity, depression and poorer overall health compared to those without such experiences, according to a study by researchers at UC San Francisco.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
APS is the association of antiphospholipid antibodies (aPL) with thromboses and/or recurrent pregnancy loss (RPL). Among patients with SLE, one-third have aPL and 10-15% have a manifestation of secondary APS. Animal studies suggested that complement activation plays an important role in the pathophysiology of thrombosis and pregnancy loss in APS. We performed a cross-sectional study on complement proteins and genes in 525 patients with aPL. Among them, 237 experienced thromboses and 293 had SLE; 111 had both SLE and thromboses, and 106 had neither SLE nor thrombosis. Complement protein levels were determined by radial immu...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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