Cell surface expression of 78-kDa glucose-regulated protein (GRP78) mediates diabetic nephropathy [Signal Transduction]

In conclusion, our work reveals a role for csGRP78 in HG-induced profibrotic responses in mesangial cells, informing a potential approach to treating diabetic nephropathy.

Source: Journal of Biological Chemistry - May 9, 2019 Category: Chemistry Authors: Richard Van Krieken, Neel Mehta, Tony Wang, Mengyu Zheng, Renzhong Li, Bo Gao, Ehab Ayaub, Kjetil Ask, James C. Paton, Adrienne W. Paton, Richard C. Austin, Joan C. Krepinsky Tags: Molecular Bases of Disease Source Type: research