Drug Stereochemistry: A Prodigy For Pharmacology And Drug Development.

This article generally includes the pharmacological profile review of some chiral drugs and the aspects by which the single enantiomer can be of significant importance as compared to the racemic mixture of the drug. This can be achieved either by assuaging the side effects or toxic effects; or by the potentiated activity of the single enantiomer. Resolution deals with the separation of racemic compounds which shows up the credibility to obtain the desired enantiomeric properties. As isomers vary in their pharmacokinetic and pharmacodynamic profiles, chiral drugs have showcased considerable importance in the drug development process. Both enantiomers have a different pharmacological profile in the treatment of a disease, which differentiates them from drug racemates. PMID: 31057115 [PubMed - as supplied by publisher]
Source: Current Drug Discovery Technologies - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Discov Technol Source Type: research