Epidermal AMBRA1 and Loricrin; a paradigm shift in the prognostication and stratification of AJCC stage I melanomas.

CONCLUSIONS: Loss of AMLo expression in the epidermis overlying primary AJCC stage I melanomas identifies high risk tumour subsets independently of Breslow depth and represents a major paradigm shift in future prognostic assessment and stratification of primary melanomas. This article is protected by copyright. All rights reserved.
PMID: 31056744 [PubMed - as supplied by publisher]

Source: The British Journal of Dermatology - May 5, 2019 Category: Dermatology Authors: Ellis R, Tang D, Nasr B, Greenwood A, McConnell A, Anagnostou ME, Elias M, Verykiou S, Bajwa D, Ewen T, Reynolds NJ, Barrett P, Carling E, Watson G, Armstrong J, Allen AJ, Horswell S, Labus M, Lovat PE Tags: Br J Dermatol Source Type: research