Microscopic colitis

Microscopic colitis describes a condition of chronic watery diarrhoea in the absence of macroscopic evidence of colonic inflammation but with characteristic microscopic appearances. It comprises the two separate but related conditions of lymphocytic and collagenous colitis. Disease severity ranges from mild and self-limiting to severe and refractory. Whereas mild disease can be managed adequately with loperamide, severe disease requires budesonide over the short term and, occasionally, immunomodulatory therapy with azathioprine.
Source: Medicine - Category: Internal Medicine Authors: Tags: Inflammatory bowel disease Source Type: research

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Abstract The yeast Saccharomyces boulardii CNCM I-745 is a unique, non-bacterial microorganism classified as a probiotic agent. In this review article, at first, we briefly summarized the mechanisms responsible for its probiotic properties, e.g. adhesion to and elimination of enteropathogenic microorganisms and their toxins; extracellular cleavage of pathogens' virulent factors; trophic and anti-inflammatory effects on the intestinal mucosa. The efficacy of S. boulardii administration was tested in variety of human diseases. We discussed the results of S. boulardii CNCM I-745 use in the treatment or prevention of ...
Source: Current Microbiology - Category: Microbiology Authors: Tags: Curr Microbiol Source Type: research
Sufferers found to have low levels of gut microbes that convert bile acids into other substancesHopes of developing a new treatment for ulcerative colitis have been raised by research suggesting the condition may be linked to low levels of certain bacteria in the gut.Ulcerative colitis is a long-term condition in whichthe colon becomes inflamed. Accordingto the NHS, it is thought to be an autoimmune disease and affects one in every 420 people in the UK. Sufferers need to empty their bowels frequently, develop ulcers in their colon and have recurring bouts of diarrhoea with blood and pus in the faeces.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Digestive disorders Science Health & wellbeing Life and style Society Source Type: news
ConclusionIn this study, the potential of S. domestica in the treatment of colitis was investigated. Fruits of this plant were found to have important anti-inflammatory and antioxidant activities. Through isolation techniques, vanillic acid 4-O-α-L-rhamnopyranoside, protocateuic acid anhydrite and trivanilloyl-(1,3,4-trihydroxybenzol) ester were determined as the main active components of the fruits. Consequently, S domestica might be a promising candidate for upcoming use the prevention and treatment of various disorders, such as inflammatory bowel diseases, irritable bowel syndrome and Clostridium difficile infecti...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionsOur study indicates that dietary P3G decreased inflammation to decrease the symptoms of IBD, and to improve cardiovascular, liver and metabolic functions in metabolic syndrome.
Source: European Journal of Nutrition - Category: Nutrition Source Type: research
Authors: Senbanjo I, Akinola A, Kumolu-Johnson T, Igbekoyi O, Oshikoya K Abstract Inflammatory bowel disease (IBD) is rare in sub-Saharan Africa. Five cases in Nigerian children are presented to highlight the occurrence, pattern of clinical presentation and management challenges. The patients were identified following a retrospective review of all diagnosed cases of IBD between 1 January 2011 and 31 December 2018 seen at the Paediatric Gastroenterology, Hepatology and Nutrition Unit of Lagos State University Teaching Hospital. The median age (range) was 9 (7-13) years. Three cases were diagnosed because bloody diar...
Source: Paediatrics and international child health - Category: Pediatrics Tags: Paediatr Int Child Health Source Type: research
ConclusionThe diagnosis of severe acute UC in elderly patients with acute abdomen had been complicated by the distinctive physiology of this aged group with atypical presentation and markedly unreliable physical examination. Eventually, severe UC should always be kept in mind with a circumstance of abdominal pain in geriatric population.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
CONCLUSIONS: 5-ASA preparations are superior to placebo for the maintenance of surgically-induced clinical remission in patients with CD (moderate certainty). The number needed to treat to prevent one relapse was 13 patients. The evidence for endoscopic remission is uncertain. The sulphasalazine class of 5-ASA agents failed to demonstrate superiority against placebo, 5-ASAs failed to demonstrate superiority compared to no treatment (very low and low certainty). The efficacy of two different doses of the same 5-ASA and the efficacy of 5-ASA compared to purine antimetabolites (azathioprine or 6-mercaptopurine) in maintaining...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
CONCLUSIONS: The disease activity and high levels of anxiety and fears influenced the psychosocial functioning of the patients with ulcerative colitis. PMID: 31232068 [PubMed - in process]
Source: Annals of Agricultural and Environmental Medicine : AAEM - Category: Environmental Health Authors: Tags: Ann Agric Environ Med Source Type: research
In this study, we found that cofilin competes with tau for direct microtubule binding in vitro, in cells, and in vivo, which inhibits tau-induced microtubule assembly. Genetic reduction of cofilin mitigates tauopathy and synaptic defects in Tau-P301S mice and movement deficits in tau transgenic C. elegans. The pathogenic effects of cofilin are selectively mediated by activated cofilin, as active but not inactive cofilin selectively interacts with tubulin, destabilizes microtubules, and promotes tauopathy. These results therefore indicate that activated cofilin plays an essential intermediary role in neurotoxic signaling th...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
is a chronic inflammatory bowel disease that can affect any part of the gastrointestinal tract from mouth to anus, although the ileum, colon and perineum are most commonly involved. It is characterized by transmural granulomatous inflammation. Crohn's disease is thought to result from a complex interplay of multiple genetic and environmental factors. Alterations in the microbiota signature with reduced microbiota diversity are observed. Diarrhoea, abdominal pain, fatigue, weight loss and fever are hallmarks of Crohn's disease.
Source: Medicine - Category: Internal Medicine Authors: Tags: Inflammatory bowel disease Source Type: research
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