Toll-like receptor 2 utilizes RAB11A for melanosome transfer from melanocytes to keratinocytes

Epidermal cells including keratinocytes express TLRs to sense the signals from the outer world and induce cytokines and antimicrobial peptides to protect the human body. TLR2 recognizes bacterial lipoprotein, lipopeptide, and peptidoglycan, and TLR2 agonists activate the MyD88-dependent pathway. We previously reported that stimulation of TLR2 and TLR3 enhances melanogenesis in melanocytes and melanosome transfer to keratinocytes [1]. TLR2 agonist HKLM increases melanin contents and melanosome release from melanocytes by enhancing expression of melanogenic genes, tyrosinase (TYR) and dopachrome tautomerase (DCT) [1].

Source: Journal of Dermatological Science - April 29, 2019 Category: Dermatology Authors: Saaya Koike, Kenshi Yamasaki, Takeshi Yamauchi, Ryoko Shimada-Omori, Kenichiro Tsuchiyama, Setsuya Aiba Tags: Letter to the Editor Source Type: research